Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man

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Standard

Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man. / Slimani, Hocine; Plaghki, Leon; Valenti, Paola; Werner, Mads U.; Kehlet, Henrik; Kupers, Ron.

I: Pain, Bind 159, Nr. 11, 11.2018, s. 2331-2338.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Slimani, H, Plaghki, L, Valenti, P, Werner, MU, Kehlet, H & Kupers, R 2018, 'Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man', Pain, bind 159, nr. 11, s. 2331-2338. https://doi.org/10.1097/j.pain.0000000000001339

APA

Slimani, H., Plaghki, L., Valenti, P., Werner, M. U., Kehlet, H., & Kupers, R. (2018). Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man. Pain, 159(11), 2331-2338. https://doi.org/10.1097/j.pain.0000000000001339

Vancouver

Slimani H, Plaghki L, Valenti P, Werner MU, Kehlet H, Kupers R. Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man. Pain. 2018 nov.;159(11):2331-2338. https://doi.org/10.1097/j.pain.0000000000001339

Author

Slimani, Hocine ; Plaghki, Leon ; Valenti, Paola ; Werner, Mads U. ; Kehlet, Henrik ; Kupers, Ron. / Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man. I: Pain. 2018 ; Bind 159, Nr. 11. s. 2331-2338.

Bibtex

@article{0d68675a95b54d9b8134c3e8c2ed489c,
title = "Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man",
abstract = "It remains unclear which nerve fibers are responsible for mediating hyperalgesia after skin injury. Here, we examined the role of Aδ and C fibers in inflammatory hyperalgesia after a first-degree burn injury. A CO2 laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg to stimulate selectively the relatively fast-conducting thinly myelinated Aδ and the slowly conducting unmyelinated C fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ and C fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1 hour and 24 hours after injury. First-degree burn injury caused a significant decrease in Aδ fiber detection thresholds and a significant increase in the proportion of Aδ-fiber-mediated responses in the inflamed area 24 hours, but not 1 hour, after burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber-mediated sensations were observed. Our findings indicate that quickly adapting Aδ fibers but not quickly adapting C fibers are sensitized when activated by short and ultrafast heat stimuli after skin burn injury. Our results further show that this change occurs between 1 hour and 24 hours after injury and that it does not extend to the skin surrounding the injury.",
keywords = "Inflammation, CO2 laser, Nociception, Thermal hyperalgesia, Pain, Burn injury",
author = "Hocine Slimani and Leon Plaghki and Paola Valenti and Werner, {Mads U.} and Henrik Kehlet and Ron Kupers",
year = "2018",
month = nov,
doi = "10.1097/j.pain.0000000000001339",
language = "English",
volume = "159",
pages = "2331--2338",
journal = "Pain",
issn = "0304-3959",
publisher = "IASP Press",
number = "11",

}

RIS

TY - JOUR

T1 - Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man

AU - Slimani, Hocine

AU - Plaghki, Leon

AU - Valenti, Paola

AU - Werner, Mads U.

AU - Kehlet, Henrik

AU - Kupers, Ron

PY - 2018/11

Y1 - 2018/11

N2 - It remains unclear which nerve fibers are responsible for mediating hyperalgesia after skin injury. Here, we examined the role of Aδ and C fibers in inflammatory hyperalgesia after a first-degree burn injury. A CO2 laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg to stimulate selectively the relatively fast-conducting thinly myelinated Aδ and the slowly conducting unmyelinated C fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ and C fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1 hour and 24 hours after injury. First-degree burn injury caused a significant decrease in Aδ fiber detection thresholds and a significant increase in the proportion of Aδ-fiber-mediated responses in the inflamed area 24 hours, but not 1 hour, after burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber-mediated sensations were observed. Our findings indicate that quickly adapting Aδ fibers but not quickly adapting C fibers are sensitized when activated by short and ultrafast heat stimuli after skin burn injury. Our results further show that this change occurs between 1 hour and 24 hours after injury and that it does not extend to the skin surrounding the injury.

AB - It remains unclear which nerve fibers are responsible for mediating hyperalgesia after skin injury. Here, we examined the role of Aδ and C fibers in inflammatory hyperalgesia after a first-degree burn injury. A CO2 laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg to stimulate selectively the relatively fast-conducting thinly myelinated Aδ and the slowly conducting unmyelinated C fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ and C fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1 hour and 24 hours after injury. First-degree burn injury caused a significant decrease in Aδ fiber detection thresholds and a significant increase in the proportion of Aδ-fiber-mediated responses in the inflamed area 24 hours, but not 1 hour, after burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber-mediated sensations were observed. Our findings indicate that quickly adapting Aδ fibers but not quickly adapting C fibers are sensitized when activated by short and ultrafast heat stimuli after skin burn injury. Our results further show that this change occurs between 1 hour and 24 hours after injury and that it does not extend to the skin surrounding the injury.

KW - Inflammation

KW - CO2 laser

KW - Nociception

KW - Thermal hyperalgesia

KW - Pain

KW - Burn injury

U2 - 10.1097/j.pain.0000000000001339

DO - 10.1097/j.pain.0000000000001339

M3 - Journal article

C2 - 29994994

AN - SCOPUS:85055080473

VL - 159

SP - 2331

EP - 2338

JO - Pain

JF - Pain

SN - 0304-3959

IS - 11

ER -

ID: 209802130