Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man
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Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man. / Slimani, Hocine; Plaghki, Leon; Valenti, Paola; Werner, Mads U.; Kehlet, Henrik; Kupers, Ron.
I: Pain, Bind 159, Nr. 11, 11.2018, s. 2331-2338.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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T1 - Aδ and not C fibers mediate thermal hyperalgesia to short laser stimuli after burn injury in man
AU - Slimani, Hocine
AU - Plaghki, Leon
AU - Valenti, Paola
AU - Werner, Mads U.
AU - Kehlet, Henrik
AU - Kupers, Ron
PY - 2018/11
Y1 - 2018/11
N2 - It remains unclear which nerve fibers are responsible for mediating hyperalgesia after skin injury. Here, we examined the role of Aδ and C fibers in inflammatory hyperalgesia after a first-degree burn injury. A CO2 laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg to stimulate selectively the relatively fast-conducting thinly myelinated Aδ and the slowly conducting unmyelinated C fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ and C fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1 hour and 24 hours after injury. First-degree burn injury caused a significant decrease in Aδ fiber detection thresholds and a significant increase in the proportion of Aδ-fiber-mediated responses in the inflamed area 24 hours, but not 1 hour, after burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber-mediated sensations were observed. Our findings indicate that quickly adapting Aδ fibers but not quickly adapting C fibers are sensitized when activated by short and ultrafast heat stimuli after skin burn injury. Our results further show that this change occurs between 1 hour and 24 hours after injury and that it does not extend to the skin surrounding the injury.
AB - It remains unclear which nerve fibers are responsible for mediating hyperalgesia after skin injury. Here, we examined the role of Aδ and C fibers in inflammatory hyperalgesia after a first-degree burn injury. A CO2 laser delivered ultrafast short constant-temperature heat pulses to the upper part of the lower leg to stimulate selectively the relatively fast-conducting thinly myelinated Aδ and the slowly conducting unmyelinated C fibers. Participants were asked to respond as fast as possible whenever they detected a thermal stimulus. Thresholds and reaction times to selective Aδ and C fiber activations were measured in the conditioned and the surrounding intact skin, at pre-injury, and 1 hour and 24 hours after injury. First-degree burn injury caused a significant decrease in Aδ fiber detection thresholds and a significant increase in the proportion of Aδ-fiber-mediated responses in the inflamed area 24 hours, but not 1 hour, after burn injury. No changes in heat perception were observed in the intact skin surrounding the injury. No group differences in C-fiber-mediated sensations were observed. Our findings indicate that quickly adapting Aδ fibers but not quickly adapting C fibers are sensitized when activated by short and ultrafast heat stimuli after skin burn injury. Our results further show that this change occurs between 1 hour and 24 hours after injury and that it does not extend to the skin surrounding the injury.
KW - Inflammation
KW - CO2 laser
KW - Nociception
KW - Thermal hyperalgesia
KW - Pain
KW - Burn injury
U2 - 10.1097/j.pain.0000000000001339
DO - 10.1097/j.pain.0000000000001339
M3 - Journal article
C2 - 29994994
AN - SCOPUS:85055080473
VL - 159
SP - 2331
EP - 2338
JO - Pain
JF - Pain
SN - 0304-3959
IS - 11
ER -
ID: 209802130