Ansatte – Københavns Universitet

A longitudinal study of growth, sex steroids and IGF-1 in boys with physiological gynaecomastia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Mikkel G. Mieritz, Lars Lau Raket, Casper P. Hagen, John E. Nielsen, Maj-Lis Møller Talman, Jørgen Holm Petersen, Stefan Horst Sommer, Katharina Maria Main, Niels Jørgensen, Anders Juul

Context: Physiological gynaecomastia is common and affects a large proportion of otherwise healthy adolescent boys. It is thought to be caused by an imbalance between estrogen and testosterone, though this is rarely evident in analyses of serum. Objective: This study aimed to describe the frequency of physiological gynaecomastia, and to determine possible etiological factors (e.g. auxology and serum hormone levels) in a longitudinal set-up. Design, Settings and Participants: A prospective cohort study of 106 healthy Danish boys (5.8–16.4 years) participated in the longitudinal part of “the COPENHAGEN Puberty Study”. The boys were examined every six months during an eight year follow-up. Median number of examinations was 10 (2–15). Main outcome measurements: Blood samples and analysed for FSH, LH, testosterone, estradiol, SHBG, inhibin B, AMH, IGF-I and IGFBP-3 by immunoassays. Auxological parameters, pubertal development and the presence of gynaecomastia were evaluated at each visit. Results: 52 of 106 boys (49 developed gynaecomastia of which 10 (19 presented with intermittent gynaecomastia. Boys with physiological gynaecomastia reached peak height velocity at a significantly younger age than boys who did not develop gynaecomastia (13.5 vs 13.9 years, p = 0.027), and they had significantly higher serum levels of IGF-I (p = 0.000), estradiol (p = 0.013), free-testosterone (p <0.001) and FSH (p = 0.030) during pubertal transition. However, no differences in serum LH or in the estradiol to testosterone ratio were found. Conclusions: Gynaecomastia is frequent in pubertal boys. Increased IGF-I levels and pubertal growth appear to be associated, whereas changes in estrogen to testosterone ratio seem negligible.
OriginalsprogEngelsk
TidsskriftJournal of Clinical Endocrinology and Metabolism
Vol/bind100
Udgave nummer10
Sider (fra-til)3752-3759
Antal sider8
ISSN0021-972X
DOI
StatusUdgivet - 2015

Bibliografisk note

PMID: 26287961

ID: 143085758