Congenital blindness affects diencephalic but not mesencephalic structures in the human brain

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Congenital blindness affects diencephalic but not mesencephalic structures in the human brain. / Cecchetti, Luca; Ricciardi, Emiliano; Handjaras, Giacomo; Kupers, Ron; Ptito, Maurice; Pietrini, Pietro.

I: Brain Structure and Function, Bind 221, Nr. 3, 2016, s. 1465-1480.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Cecchetti, L, Ricciardi, E, Handjaras, G, Kupers, R, Ptito, M & Pietrini, P 2016, 'Congenital blindness affects diencephalic but not mesencephalic structures in the human brain', Brain Structure and Function, bind 221, nr. 3, s. 1465-1480. https://doi.org/10.1007/s00429-014-0984-5

APA

Cecchetti, L., Ricciardi, E., Handjaras, G., Kupers, R., Ptito, M., & Pietrini, P. (2016). Congenital blindness affects diencephalic but not mesencephalic structures in the human brain. Brain Structure and Function, 221(3), 1465-1480. https://doi.org/10.1007/s00429-014-0984-5

Vancouver

Cecchetti L, Ricciardi E, Handjaras G, Kupers R, Ptito M, Pietrini P. Congenital blindness affects diencephalic but not mesencephalic structures in the human brain. Brain Structure and Function. 2016;221(3):1465-1480. https://doi.org/10.1007/s00429-014-0984-5

Author

Cecchetti, Luca ; Ricciardi, Emiliano ; Handjaras, Giacomo ; Kupers, Ron ; Ptito, Maurice ; Pietrini, Pietro. / Congenital blindness affects diencephalic but not mesencephalic structures in the human brain. I: Brain Structure and Function. 2016 ; Bind 221, Nr. 3. s. 1465-1480.

Bibtex

@article{35637358207b4d46b2c6f61336f09f8a,
title = "Congenital blindness affects diencephalic but not mesencephalic structures in the human brain",
abstract = "While there is ample evidence that the structure and function of visual cortical areas are affected by early visual deprivation, little is known of how early blindness modifies subcortical relay and association thalamic nuclei, as well as mesencephalic structures. Therefore, in the present multicenter study, we used MRI to measure volume of the superior and inferior colliculi, as well as of the thalamic nuclei relaying sensory and motor information to the neocortex, parcellated according to atlas-based thalamo-cortical connections, in 29 individuals with congenital blindness of peripheral origin (17 M, age 35.7 ± 14.3 years) and 29 sighted subjects (17 M, age 31.9 ± 9.0). Blind participants showed an overall volume reduction in the left (p = 0.008) and right (p = 0.007) thalami, as compared to the sighted individuals. Specifically, the lateral geniculate (i.e., primary visual thalamic relay nucleus) was 40 % reduced (left: p = 4 × 10−6, right: p < 1 × 10−6), consistent with findings from animal studies. In addition, associated thalamic nuclei that project to temporal (left: p = 0.005, right: p = 0.005), prefrontal (left: p = 0.010, right: p = 0.014), occipital (left: p = 0.005, right: p = 0.023), and right premotor (p = 0.024) cortical regions were also significantly reduced in the congenitally blind group. Conversely, volumes of the relay nuclei directly involved in auditory, motor, and somatosensory processing were not affected by visual deprivation. In contrast, no difference in volume was observed in either the superior or the inferior colliculus between the two groups. Our findings indicate that visual loss since birth leads to selective volumetric changes within diencephalic, but not mesencephalic, structures. Both changes in reciprocal cortico-thalamic connections or modifications in the intrinsic connectivity between relay and association nuclei of the thalamus may contribute to explain these alterations in thalamic volumes. Sparing of the superior colliculi is in line with their composite, multisensory projections, and with their not exclusive visual nature.",
keywords = "Congenital blindness, Lateral geniculate nucleus, Morphometry, Superior colliculus, Thalamus",
author = "Luca Cecchetti and Emiliano Ricciardi and Giacomo Handjaras and Ron Kupers and Maurice Ptito and Pietro Pietrini",
year = "2016",
doi = "10.1007/s00429-014-0984-5",
language = "English",
volume = "221",
pages = "1465--1480",
journal = "Brain Structure and Function",
issn = "1863-2653",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Congenital blindness affects diencephalic but not mesencephalic structures in the human brain

AU - Cecchetti, Luca

AU - Ricciardi, Emiliano

AU - Handjaras, Giacomo

AU - Kupers, Ron

AU - Ptito, Maurice

AU - Pietrini, Pietro

PY - 2016

Y1 - 2016

N2 - While there is ample evidence that the structure and function of visual cortical areas are affected by early visual deprivation, little is known of how early blindness modifies subcortical relay and association thalamic nuclei, as well as mesencephalic structures. Therefore, in the present multicenter study, we used MRI to measure volume of the superior and inferior colliculi, as well as of the thalamic nuclei relaying sensory and motor information to the neocortex, parcellated according to atlas-based thalamo-cortical connections, in 29 individuals with congenital blindness of peripheral origin (17 M, age 35.7 ± 14.3 years) and 29 sighted subjects (17 M, age 31.9 ± 9.0). Blind participants showed an overall volume reduction in the left (p = 0.008) and right (p = 0.007) thalami, as compared to the sighted individuals. Specifically, the lateral geniculate (i.e., primary visual thalamic relay nucleus) was 40 % reduced (left: p = 4 × 10−6, right: p < 1 × 10−6), consistent with findings from animal studies. In addition, associated thalamic nuclei that project to temporal (left: p = 0.005, right: p = 0.005), prefrontal (left: p = 0.010, right: p = 0.014), occipital (left: p = 0.005, right: p = 0.023), and right premotor (p = 0.024) cortical regions were also significantly reduced in the congenitally blind group. Conversely, volumes of the relay nuclei directly involved in auditory, motor, and somatosensory processing were not affected by visual deprivation. In contrast, no difference in volume was observed in either the superior or the inferior colliculus between the two groups. Our findings indicate that visual loss since birth leads to selective volumetric changes within diencephalic, but not mesencephalic, structures. Both changes in reciprocal cortico-thalamic connections or modifications in the intrinsic connectivity between relay and association nuclei of the thalamus may contribute to explain these alterations in thalamic volumes. Sparing of the superior colliculi is in line with their composite, multisensory projections, and with their not exclusive visual nature.

AB - While there is ample evidence that the structure and function of visual cortical areas are affected by early visual deprivation, little is known of how early blindness modifies subcortical relay and association thalamic nuclei, as well as mesencephalic structures. Therefore, in the present multicenter study, we used MRI to measure volume of the superior and inferior colliculi, as well as of the thalamic nuclei relaying sensory and motor information to the neocortex, parcellated according to atlas-based thalamo-cortical connections, in 29 individuals with congenital blindness of peripheral origin (17 M, age 35.7 ± 14.3 years) and 29 sighted subjects (17 M, age 31.9 ± 9.0). Blind participants showed an overall volume reduction in the left (p = 0.008) and right (p = 0.007) thalami, as compared to the sighted individuals. Specifically, the lateral geniculate (i.e., primary visual thalamic relay nucleus) was 40 % reduced (left: p = 4 × 10−6, right: p < 1 × 10−6), consistent with findings from animal studies. In addition, associated thalamic nuclei that project to temporal (left: p = 0.005, right: p = 0.005), prefrontal (left: p = 0.010, right: p = 0.014), occipital (left: p = 0.005, right: p = 0.023), and right premotor (p = 0.024) cortical regions were also significantly reduced in the congenitally blind group. Conversely, volumes of the relay nuclei directly involved in auditory, motor, and somatosensory processing were not affected by visual deprivation. In contrast, no difference in volume was observed in either the superior or the inferior colliculus between the two groups. Our findings indicate that visual loss since birth leads to selective volumetric changes within diencephalic, but not mesencephalic, structures. Both changes in reciprocal cortico-thalamic connections or modifications in the intrinsic connectivity between relay and association nuclei of the thalamus may contribute to explain these alterations in thalamic volumes. Sparing of the superior colliculi is in line with their composite, multisensory projections, and with their not exclusive visual nature.

KW - Congenital blindness

KW - Lateral geniculate nucleus

KW - Morphometry

KW - Superior colliculus

KW - Thalamus

U2 - 10.1007/s00429-014-0984-5

DO - 10.1007/s00429-014-0984-5

M3 - Journal article

C2 - 25560311

AN - SCOPUS:84922343335

VL - 221

SP - 1465

EP - 1480

JO - Brain Structure and Function

JF - Brain Structure and Function

SN - 1863-2653

IS - 3

ER -

ID: 179044305