Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year: a longitudinal analysis from Osteoarthritis Initiative

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

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  • Farhad Pishgar
  • Amir Ashraf-Ganjouei
  • Mahsa Dolatshahi
  • Ali Guermazi
  • Bashir Zikria
  • Xu Cao
  • Mei Wan
  • Frank W Roemer
  • Dam, Erik Bjørnager
  • Shadpour Demehri

OBJECTIVE: To study associations between MRI-derived subchondral trabecular biomarkers obtained from conventional MRI sequences and knee cartilage loss over 12 and 24 months, using the FNIH osteoarthritis (OA) biomarkers consortium.

MATERIALS AND METHODS: Data of the 600 subjects in the FNIH OA biomarkers consortium (a nested case-control study within Osteoarthritis Initiative [OAI]) were extracted from the online database. Baseline knee MRI (intermediate-weighted (IW) sequences) were evaluated to determine conventional MRI-derived trabecular thickness (cTbTh) and bone-to-total ratio (cBV/TV). The measurements for medial and lateral volumes of cartilages using baseline, 12-, and 24-month knee MRI were extracted from the OAI database, and cartilage volume loss over 12 and 24 months of follow-up were determined using Relative Change Index. The association between conventional MRI-based subchondral trabecular biomarkers and cartilage volume loss were studied using logistic regression models, adjusted for relevant confounders including age, sex, body mass index (BMI), vitamin D use, Kellgren Lawrence grade (KLG), and tibiofemoral alignment.

RESULTS: Higher medial cTbTh and cBV/TV at baseline were associated with increased odds of medial tibial cartilage volume loss over 12 months (ORs: 1.01 [1.00-1.02] and 1.24 [1.10-1.39] per 1-SD change) and 24 months (ORs: 1.01 [1.00-1.02] and 1.22 [1.08-1.37], per 1-SD change). No significant association was observed between medial subchondral trabecular biomarkers and lateral tibial or femoral (medial or lateral) cartilage volume loss over the first and second follow-up years.

CONCLUSIONS: Conventional MRI-derived subchondral trabecular biomarkers (higher medial cTbTh and cBV/TV) may be associated with increased medial tibial cartilage volume loss as early as 1 year.

OriginalsprogEngelsk
TidsskriftSkeletal Radiology
Vol/bind51
Sider (fra-til)1959–1966
ISSN0364-2348
DOI
StatusUdgivet - 2022

Bibliografisk note

© 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).

ID: 302809097