Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women
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Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women. / Ganz, Melanie; de Bruijne, Marleen; Dam, Erik B.; Pettersen, Paola; Karsdal, Morten A.; Christiansen, Claus; Nielsen, Mads.
I: International Journal of Biomedical Imaging, Bind 2012, 459286, 2012.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Distribution, size, and shape of abdominal aortic calcified deposits and their relationship to mortality in postmenopausal women
AU - Ganz, Melanie
AU - de Bruijne, Marleen
AU - Dam, Erik B.
AU - Pettersen, Paola
AU - Karsdal, Morten A.
AU - Christiansen, Claus
AU - Nielsen, Mads
PY - 2012
Y1 - 2012
N2 - Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascularmortality.We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognosticmarkers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausalwomen, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of theirarea, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictiveability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated areapercentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjustingfor traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number ofcalcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified fromradiographs may be a useful tool for screening and monitoring risk of CVD mortality.
AB - Abdominal aortic calcifications (AACs) correlate strongly with coronary artery calcifications and can be predictors of cardiovascularmortality.We investigated whether size, shape, and distribution of AACs are related to mortality and how such prognosticmarkers perform compared to the state-of-the-art AC24 marker introduced by Kauppila. Methods. For 308 postmenopausalwomen, we quantified the number of AAC and the percentage of the abdominal aorta that the lesions occupied in terms of theirarea, simulated plaque area, thickness, wall coverage, and length. We analysed inter-/intraobserver reproducibility and predictiveability of mortality after 8-9 years via Cox regression leading to hazard ratios (HRs). Results. The coefficient of variation was below25% for all markers. The strongest individual predictors were the number of calcifications (HR = 2.4) and the simulated areapercentage (HR = 2.96) of a calcified plaque, and, unlike AC24 (HR = 1.66), they allowed mortality prediction also after adjustingfor traditional risk factors. In a combined Cox regression model, the strongest complementary predictors were the number ofcalcifications (HR = 2.76) and the area percentage (HR = -3.84). Conclusion. Morphometric markers of AAC quantified fromradiographs may be a useful tool for screening and monitoring risk of CVD mortality.
U2 - 10.1155/2012/459286
DO - 10.1155/2012/459286
M3 - Journal article
C2 - 22719751
VL - 2012
JO - International Journal of Biomedical Imaging
JF - International Journal of Biomedical Imaging
SN - 1687-4188
M1 - 459286
ER -
ID: 38289880