Identification of progressors in osteoarthritis by combining biochemical and MRI based markers.
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Identification of progressors in osteoarthritis by combining biochemical and MRI based markers. / Dam, Erik Bjørnager; Loog, Marco; Christiansen, Claus; Byrjalsen, Inger; Folkesson, Jenny Maria; Nielsen, Mads; Qazi, Arish Asif; Pettersen, Paola; Garnero, Patrick; Karsdal, Morten A.
I: Arthritis Research & Therapy, Bind 11, Nr. 4, 24.07.2009, s. 1-11.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Identification of progressors in osteoarthritis by combining biochemical and MRI based markers.
AU - Dam, Erik Bjørnager
AU - Loog, Marco
AU - Christiansen, Claus
AU - Byrjalsen, Inger
AU - Folkesson, Jenny Maria
AU - Nielsen, Mads
AU - Qazi, Arish Asif
AU - Pettersen, Paola
AU - Garnero, Patrick
AU - Karsdal, Morten A
PY - 2009/7/24
Y1 - 2009/7/24
N2 - At present, no disease-modifying osteoarthritis drugs (DMOADS) are approved by the FDA (US Food and Drug Administration); possibly partly due to inadequate trial design since efficacy demonstration requires disease progression in the placebo group. We investigated whether combinations of biochemical and magnetic resonance imaging (MRI)-based markers provided effective diagnostic and prognostic tools for identifying subjects with high risk of progression. Specifically, we investigated aggregate cartilage longevity markers combining markers of breakdown, quantity, and quality.
AB - At present, no disease-modifying osteoarthritis drugs (DMOADS) are approved by the FDA (US Food and Drug Administration); possibly partly due to inadequate trial design since efficacy demonstration requires disease progression in the placebo group. We investigated whether combinations of biochemical and magnetic resonance imaging (MRI)-based markers provided effective diagnostic and prognostic tools for identifying subjects with high risk of progression. Specifically, we investigated aggregate cartilage longevity markers combining markers of breakdown, quantity, and quality.
U2 - 10.1186/ar2774
DO - 10.1186/ar2774
M3 - Journal article
C2 - 19630944
VL - 11
SP - 1
EP - 11
JO - Arthritis Research & Therapy
JF - Arthritis Research & Therapy
SN - 1478-6354
IS - 4
ER -
ID: 18339138