MACD - an imaging marker for cardiovascular disease

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

Standard

MACD - an imaging marker for cardiovascular disease. / Ganz, Melanie; de Bruijne, Marleen; Nielsen, Mads.

Medical Imaging 2010: computer-aided diagnosis. red. / Nico Karssemeijer; Ronald M. Summers. SPIE - International Society for Optical Engineering, 2010. 76240.

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

Harvard

Ganz, M, de Bruijne, M & Nielsen, M 2010, MACD - an imaging marker for cardiovascular disease. i N Karssemeijer & RM Summers (red), Medical Imaging 2010: computer-aided diagnosis., 76240, SPIE - International Society for Optical Engineering, Medical Imaging 2010, San Diego, USA, 16/02/2010. https://doi.org/10.1117/12.844164

APA

Ganz, M., de Bruijne, M., & Nielsen, M. (2010). MACD - an imaging marker for cardiovascular disease. I N. Karssemeijer, & R. M. Summers (red.), Medical Imaging 2010: computer-aided diagnosis [76240] SPIE - International Society for Optical Engineering. https://doi.org/10.1117/12.844164

Vancouver

Ganz M, de Bruijne M, Nielsen M. MACD - an imaging marker for cardiovascular disease. I Karssemeijer N, Summers RM, red., Medical Imaging 2010: computer-aided diagnosis. SPIE - International Society for Optical Engineering. 2010. 76240 https://doi.org/10.1117/12.844164

Author

Ganz, Melanie ; de Bruijne, Marleen ; Nielsen, Mads. / MACD - an imaging marker for cardiovascular disease. Medical Imaging 2010: computer-aided diagnosis. red. / Nico Karssemeijer ; Ronald M. Summers. SPIE - International Society for Optical Engineering, 2010.

Bibtex

@inproceedings{de0d39c0632611df928f000ea68e967b,
title = "MACD - an imaging marker for cardiovascular disease",
abstract = "Despite general acceptance that a healthy lifestyle and the treatment of risk factors can prevent the development of cardiovascular diseases (CVD), CVD are the most common cause of death in Europe and the United States. It has been shown that abdominal aortic calcifications (AAC) correlate strongly with coronary artery calcifications. Hence an early detection of aortic calcified plaques helps to predict the risk of related coronary diseases. Also since two thirds of the adverse events have no prior symptoms, possibilities to screen for risk in low cost imaging are important. To this end the Morphological Atherosclerotic Calcification Distribution (MACD) index was developed. In the following several potential severity scores relating to the geometrical outline of the calcified deposits in the lumbar aortic region are introduced. Their individual as well as their combined predictive power is examined and a combined marker, MACD, is constructed. This is done using a Cox regression analysis, also known as survival analysis. Furthermore we show how a Cox regression yields MACD to be the most efficient marker. We also demonstrate that MACD has a larger individual predictive power than any of the other individual imaging markers described. Finally we present that the MACD index predicts cardiovascular death with a hazard ratio of approximately four.",
author = "Melanie Ganz and {de Bruijne}, Marleen and Mads Nielsen",
year = "2010",
doi = "10.1117/12.844164",
language = "English",
editor = "Nico Karssemeijer and Summers, {Ronald M.}",
booktitle = "Medical Imaging 2010",
publisher = "SPIE - International Society for Optical Engineering",
note = "Medical Imaging 2010 : computer-aided diagnosis ; Conference date: 16-02-2010 Through 18-02-2010",

}

RIS

TY - GEN

T1 - MACD - an imaging marker for cardiovascular disease

AU - Ganz, Melanie

AU - de Bruijne, Marleen

AU - Nielsen, Mads

PY - 2010

Y1 - 2010

N2 - Despite general acceptance that a healthy lifestyle and the treatment of risk factors can prevent the development of cardiovascular diseases (CVD), CVD are the most common cause of death in Europe and the United States. It has been shown that abdominal aortic calcifications (AAC) correlate strongly with coronary artery calcifications. Hence an early detection of aortic calcified plaques helps to predict the risk of related coronary diseases. Also since two thirds of the adverse events have no prior symptoms, possibilities to screen for risk in low cost imaging are important. To this end the Morphological Atherosclerotic Calcification Distribution (MACD) index was developed. In the following several potential severity scores relating to the geometrical outline of the calcified deposits in the lumbar aortic region are introduced. Their individual as well as their combined predictive power is examined and a combined marker, MACD, is constructed. This is done using a Cox regression analysis, also known as survival analysis. Furthermore we show how a Cox regression yields MACD to be the most efficient marker. We also demonstrate that MACD has a larger individual predictive power than any of the other individual imaging markers described. Finally we present that the MACD index predicts cardiovascular death with a hazard ratio of approximately four.

AB - Despite general acceptance that a healthy lifestyle and the treatment of risk factors can prevent the development of cardiovascular diseases (CVD), CVD are the most common cause of death in Europe and the United States. It has been shown that abdominal aortic calcifications (AAC) correlate strongly with coronary artery calcifications. Hence an early detection of aortic calcified plaques helps to predict the risk of related coronary diseases. Also since two thirds of the adverse events have no prior symptoms, possibilities to screen for risk in low cost imaging are important. To this end the Morphological Atherosclerotic Calcification Distribution (MACD) index was developed. In the following several potential severity scores relating to the geometrical outline of the calcified deposits in the lumbar aortic region are introduced. Their individual as well as their combined predictive power is examined and a combined marker, MACD, is constructed. This is done using a Cox regression analysis, also known as survival analysis. Furthermore we show how a Cox regression yields MACD to be the most efficient marker. We also demonstrate that MACD has a larger individual predictive power than any of the other individual imaging markers described. Finally we present that the MACD index predicts cardiovascular death with a hazard ratio of approximately four.

U2 - 10.1117/12.844164

DO - 10.1117/12.844164

M3 - Article in proceedings

BT - Medical Imaging 2010

A2 - Karssemeijer, Nico

A2 - Summers, Ronald M.

PB - SPIE - International Society for Optical Engineering

T2 - Medical Imaging 2010

Y2 - 16 February 2010 through 18 February 2010

ER -

ID: 19820387