MRI Biomarkers Improve Disease Progression Modeling-Based Prediction of Cognitive Decline
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
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MRI Biomarkers Improve Disease Progression Modeling-Based Prediction of Cognitive Decline. / Mehdipour Ghazi, Mostafa; Nielsen, Mads; Pai, Akshay Sadananda Uppinakudru; Modat , Marc ; Cardoso , Jorge ; Ourselin, Sebastien; Sorensen, Lauge .
2019. Abstract fra RSNA 2019 - 105th Scientific Assembly and Annual Meeting, Chicago, USA.Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
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T1 - MRI Biomarkers Improve Disease Progression Modeling-Based Prediction of Cognitive Decline
AU - Mehdipour Ghazi, Mostafa
AU - Nielsen, Mads
AU - Pai, Akshay Sadananda Uppinakudru
AU - Modat , Marc
AU - Cardoso , Jorge
AU - Ourselin, Sebastien
AU - Sorensen, Lauge
PY - 2019
Y1 - 2019
N2 - PURPOSE To investigate if volumetric MRI biomarkers help across both parametric and nonparametric Alzheimer's disease (AD) progression modeling using neuropsychological tests for decline prediction of mini-mental state examination (MMSE) score in converting and stable mild cognitive impairment (MCI) subjects. METHOD AND MATERIALS The study dataset consisted of yearly visits (2005-2016) for 372 Alzheimer's Disease Neuroimaging Initiative subjects with normal cognition, MCI, and AD, including the following measurements: FreeSurfer-based T1-weighted brain MRI volumes of ventricles, hippocampus, whole brain, fusiform, middle temporal gyrus, and entorhinal cortex, all normalized with intracranial volume, and cognitive tests of MMSE, CDR-SB, and ADAS-Cog. Two state-of-the-art disease progression modeling methods, a nonparametric [DOI:10.1016/j.media.2019.01.004] and a parametric [DOI:10.1016/j.neurobiolaging.2014.03.043], were trained on the data with and without MRI biomarkers using 336 subjects and were subsequently applied to predict month 24 to 60 MMSE scores for 36 independent test subjects based on only their baseline and month 12 visits. RESULTS The predictive power and prognostic capability of the AD progression modeling methods were assessed using the per-visit mean absolute error (MAE) and area under the ROC curve (AUC) of predicted MMSE scores for stable (MCI-to-MCI) and converting (MCI-to-AD) test subjects. The MAE results for month 24 to 60 were as follows: parametric-MRI 1.23 to 4.41 (stable), 1.54 to 11.57 (converting); parametric+MRI 1.09 to 4.39 (stable), 1.72 to 10.98 (converting); nonparametric-MRI 0.93 to 5.27 (stable), 1.62 to 8.28 (converting); nonparametric+MRI 0.23 to 0.46 (stable), 1.63 to 6.79 (converting). The AUC results for month 24 to 60 were as follows (p < 0.01): parametric-MRI 0.90 for all visits; parametric+MRI 0.89 to 0.91; nonparametric-MRI 0.86 to 0.89; nonparametric+MRI 0.85 to 0.95. CONCLUSION MRI measurements improve neuropsychological assessment-based disease progression modeling performance of both parametric and non-parametric methods in MMSE decline prediction. Predictions from both utilized methods can significantly discriminate between stable MCI and MCI converting to AD.
AB - PURPOSE To investigate if volumetric MRI biomarkers help across both parametric and nonparametric Alzheimer's disease (AD) progression modeling using neuropsychological tests for decline prediction of mini-mental state examination (MMSE) score in converting and stable mild cognitive impairment (MCI) subjects. METHOD AND MATERIALS The study dataset consisted of yearly visits (2005-2016) for 372 Alzheimer's Disease Neuroimaging Initiative subjects with normal cognition, MCI, and AD, including the following measurements: FreeSurfer-based T1-weighted brain MRI volumes of ventricles, hippocampus, whole brain, fusiform, middle temporal gyrus, and entorhinal cortex, all normalized with intracranial volume, and cognitive tests of MMSE, CDR-SB, and ADAS-Cog. Two state-of-the-art disease progression modeling methods, a nonparametric [DOI:10.1016/j.media.2019.01.004] and a parametric [DOI:10.1016/j.neurobiolaging.2014.03.043], were trained on the data with and without MRI biomarkers using 336 subjects and were subsequently applied to predict month 24 to 60 MMSE scores for 36 independent test subjects based on only their baseline and month 12 visits. RESULTS The predictive power and prognostic capability of the AD progression modeling methods were assessed using the per-visit mean absolute error (MAE) and area under the ROC curve (AUC) of predicted MMSE scores for stable (MCI-to-MCI) and converting (MCI-to-AD) test subjects. The MAE results for month 24 to 60 were as follows: parametric-MRI 1.23 to 4.41 (stable), 1.54 to 11.57 (converting); parametric+MRI 1.09 to 4.39 (stable), 1.72 to 10.98 (converting); nonparametric-MRI 0.93 to 5.27 (stable), 1.62 to 8.28 (converting); nonparametric+MRI 0.23 to 0.46 (stable), 1.63 to 6.79 (converting). The AUC results for month 24 to 60 were as follows (p < 0.01): parametric-MRI 0.90 for all visits; parametric+MRI 0.89 to 0.91; nonparametric-MRI 0.86 to 0.89; nonparametric+MRI 0.85 to 0.95. CONCLUSION MRI measurements improve neuropsychological assessment-based disease progression modeling performance of both parametric and non-parametric methods in MMSE decline prediction. Predictions from both utilized methods can significantly discriminate between stable MCI and MCI converting to AD.
UR - http://archive.rsna.org/2019/19022191.html
M3 - Conference abstract for conference
Y2 - 1 December 2019 through 4 December 2019
ER -
ID: 239621366