Multiple chemical sensitivity: on the scent of central sensitization
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Multiple chemical sensitivity : on the scent of central sensitization. / Tran, Marie Thi Dao; Arendt-Nielsen, Lars; Kupers, Ron; Elberling, Jesper.
I: International Journal of Hygiene and Environmental Health, Bind 216, Nr. 2, 03.2013, s. 202-10.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Multiple chemical sensitivity
T2 - on the scent of central sensitization
AU - Tran, Marie Thi Dao
AU - Arendt-Nielsen, Lars
AU - Kupers, Ron
AU - Elberling, Jesper
N1 - Copyright © 2012 Elsevier GmbH. All rights reserved.
PY - 2013/3
Y1 - 2013/3
N2 - BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor contributing to the clinical manifestations.PURPOSE: To use quantitative sensory testing (QST) to study central hyperexcitability and multiple aspects of central sensory processing in MCS patients without comorbid overlapping disorders and to compare the results with those among matched controls.METHODS: 15 MCS patients and 15 healthy matched controls underwent QST to assess the following aspects of pain: capsaicin-induced secondary punctate hyperalgesia, stimulus response function (SRF) to punctate mechanical stimuli before and after capsaicin injection, temporal summation to punctate stimuli post capsaicin injection, pressure pain thresholds, heat pain thresholds, tonic heat stimulation and conditioning pain modulation (CPM: formerly known as diffuse noxious inhibitory control or DNIC).RESULTS: The mean area of capsaicin-induced secondary punctate hyperalgesia was significantly larger in MCS patients than in controls at 5, 30 and 60 min post capsaicin injection (p=0.01). In addition MCS patients reported higher ratings in response to punctate mechanical stimuli assessed by SRF compared with controls (p<0.001). The CPM test induced significantly higher pain ratings in patients than in controls (p=0.002). We found no group differences in pressure pain and heat pain thresholds, temporal summation to punctate stimuli post capsaicin injection, capsaicin and tonic heat pain ratings or CPM effect.CONCLUSION: Increased capsaicin-induced secondary punctate hyperalgesia was demonstrated in MCS patients without comorbid, overlapping disorders, suggesting facilitated central sensitization in MCS.
AB - BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor contributing to the clinical manifestations.PURPOSE: To use quantitative sensory testing (QST) to study central hyperexcitability and multiple aspects of central sensory processing in MCS patients without comorbid overlapping disorders and to compare the results with those among matched controls.METHODS: 15 MCS patients and 15 healthy matched controls underwent QST to assess the following aspects of pain: capsaicin-induced secondary punctate hyperalgesia, stimulus response function (SRF) to punctate mechanical stimuli before and after capsaicin injection, temporal summation to punctate stimuli post capsaicin injection, pressure pain thresholds, heat pain thresholds, tonic heat stimulation and conditioning pain modulation (CPM: formerly known as diffuse noxious inhibitory control or DNIC).RESULTS: The mean area of capsaicin-induced secondary punctate hyperalgesia was significantly larger in MCS patients than in controls at 5, 30 and 60 min post capsaicin injection (p=0.01). In addition MCS patients reported higher ratings in response to punctate mechanical stimuli assessed by SRF compared with controls (p<0.001). The CPM test induced significantly higher pain ratings in patients than in controls (p=0.002). We found no group differences in pressure pain and heat pain thresholds, temporal summation to punctate stimuli post capsaicin injection, capsaicin and tonic heat pain ratings or CPM effect.CONCLUSION: Increased capsaicin-induced secondary punctate hyperalgesia was demonstrated in MCS patients without comorbid, overlapping disorders, suggesting facilitated central sensitization in MCS.
KW - Adult
KW - Capsaicin
KW - Central Nervous System Sensitization
KW - Cold Temperature
KW - Female
KW - Hot Temperature
KW - Humans
KW - Hyperalgesia
KW - Male
KW - Middle Aged
KW - Multiple Chemical Sensitivity
KW - Pain Measurement
KW - Questionnaires
U2 - 10.1016/j.ijheh.2012.02.010
DO - 10.1016/j.ijheh.2012.02.010
M3 - Journal article
C2 - 22487274
VL - 216
SP - 202
EP - 210
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
SN - 1438-4639
IS - 2
ER -
ID: 119769463