Reorganization of Sound Location Processing in the Auditory Cortex of Blind Humans
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Reorganization of Sound Location Processing in the Auditory Cortex of Blind Humans. / Van Der Heijden, Kiki; Formisano, Elia; Valente, Giancarlo; Zhan, Minye; Kupers, Ron; De Gelder, Beatrice.
I: Cerebral Cortex, Bind 30, Nr. 3, 2020, s. 1103-1116.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Reorganization of Sound Location Processing in the Auditory Cortex of Blind Humans
AU - Van Der Heijden, Kiki
AU - Formisano, Elia
AU - Valente, Giancarlo
AU - Zhan, Minye
AU - Kupers, Ron
AU - De Gelder, Beatrice
PY - 2020
Y1 - 2020
N2 - Auditory spatial tasks induce functional activation in the occipital - visual - cortex of early blind humans. Less is known about the effects of blindness on auditory spatial processing in the temporal - auditory - cortex. Here, we investigated spatial (azimuth) processing in congenitally and early blind humans with a phase-encoding functional magnetic resonance imaging (fMRI) paradigm. Our results show that functional activation in response to sounds in general - independent of sound location - was stronger in the occipital cortex but reduced in the medial temporal cortex of blind participants in comparison with sighted participants. Additionally, activation patterns for binaural spatial processing were different for sighted and blind participants in planum temporale. Finally, fMRI responses in the auditory cortex of blind individuals carried less information on sound azimuth position than those in sighted individuals, as assessed with a 2-channel, opponent coding model for the cortical representation of sound azimuth. These results indicate that early visual deprivation results in reorganization of binaural spatial processing in the auditory cortex and that blind individuals may rely on alternative mechanisms for processing azimuth position.
AB - Auditory spatial tasks induce functional activation in the occipital - visual - cortex of early blind humans. Less is known about the effects of blindness on auditory spatial processing in the temporal - auditory - cortex. Here, we investigated spatial (azimuth) processing in congenitally and early blind humans with a phase-encoding functional magnetic resonance imaging (fMRI) paradigm. Our results show that functional activation in response to sounds in general - independent of sound location - was stronger in the occipital cortex but reduced in the medial temporal cortex of blind participants in comparison with sighted participants. Additionally, activation patterns for binaural spatial processing were different for sighted and blind participants in planum temporale. Finally, fMRI responses in the auditory cortex of blind individuals carried less information on sound azimuth position than those in sighted individuals, as assessed with a 2-channel, opponent coding model for the cortical representation of sound azimuth. These results indicate that early visual deprivation results in reorganization of binaural spatial processing in the auditory cortex and that blind individuals may rely on alternative mechanisms for processing azimuth position.
KW - auditory cortex
KW - blindness
KW - cortical plasticity
KW - functional magnetic resonance imaging
KW - sound localization
U2 - 10.1093/cercor/bhz151
DO - 10.1093/cercor/bhz151
M3 - Journal article
C2 - 31504283
AN - SCOPUS:85083042199
VL - 30
SP - 1103
EP - 1116
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 3
ER -
ID: 242707483