TY - JOUR

T1 - Unsupervised deep learning applied to breast density segmentation and mammographic risk scoring

AU - Kallenberg, Michiel Gijsbertus J.

AU - Petersen, Peter Kersten

AU - Nielsen, Mads

AU - Ng, Andrew Y.

AU - Diao, Pengfei

AU - Igel, Christian

AU - Vachon, Celine M.

AU - Holland, Katharina

AU - Winkel, Rikke Rass

AU - Karssemeijer, Nico

AU - Lillholm, Martin

PY - 2016

Y1 - 2016

N2 - Mammographic risk scoring has commonly been automated by extracting a set of handcrafted features from mammograms, and relating the responses directly or indirectly to breast cancer risk. We present a method that learns a feature hierarchy from unlabeled data. When the learned features are used as the input to a simple classifier, two different tasks can be addressed: i) breast density segmentation, and ii) scoring of mammographic texture. The proposed model learns features at multiple scales. To control the models capacity a novel sparsity regularizer is introduced that incorporates both lifetime and population sparsity. We evaluated our method on three different clinical datasets. Our state-of-the-art results show that the learned breast density scores have a very strong positive relationship with manual ones, and that the learned texture scores are predictive of breast cancer. The model is easy to apply and generalizes to many other segmentation and scoring problems.

AB - Mammographic risk scoring has commonly been automated by extracting a set of handcrafted features from mammograms, and relating the responses directly or indirectly to breast cancer risk. We present a method that learns a feature hierarchy from unlabeled data. When the learned features are used as the input to a simple classifier, two different tasks can be addressed: i) breast density segmentation, and ii) scoring of mammographic texture. The proposed model learns features at multiple scales. To control the models capacity a novel sparsity regularizer is introduced that incorporates both lifetime and population sparsity. We evaluated our method on three different clinical datasets. Our state-of-the-art results show that the learned breast density scores have a very strong positive relationship with manual ones, and that the learned texture scores are predictive of breast cancer. The model is easy to apply and generalizes to many other segmentation and scoring problems.

U2 - 10.1109/TMI.2016.2532122

DO - 10.1109/TMI.2016.2532122

M3 - Journal article

C2 - 26915120

VL - 35

SP - 1322

EP - 1331

JO - I E E E Transactions on Medical Imaging

JF - I E E E Transactions on Medical Imaging

SN - 0278-0062

IS - 5

ER -