The structure of the serotonin system: A PET imaging study

Research output: Contribution to journal › Journal article › peer-review

Standard

The structure of the serotonin system : A PET imaging study. / Beliveau, Vincent; Ozenne, Brice; Strother, Stephen; Greve, Douglas N.; Svarer, Claus; Knudsen, Gitte Moos; Ganz, Melanie.

In: NeuroImage, Vol. 205, 116240, 2020.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Beliveau, V, Ozenne, B, Strother, S, Greve, DN, Svarer, C, Knudsen, GM & Ganz, M 2020, 'The structure of the serotonin system: A PET imaging study', NeuroImage, vol. 205, 116240. https://doi.org/10.1016/j.neuroimage.2019.116240

APA

Beliveau, V., Ozenne, B., Strother, S., Greve, D. N., Svarer, C., Knudsen, G. M., & Ganz, M. (2020). The structure of the serotonin system: A PET imaging study. NeuroImage, 205, [116240]. https://doi.org/10.1016/j.neuroimage.2019.116240

Vancouver

Beliveau V, Ozenne B, Strother S, Greve DN, Svarer C, Knudsen GM et al. The structure of the serotonin system: A PET imaging study. NeuroImage. 2020;205. 116240. https://doi.org/10.1016/j.neuroimage.2019.116240

Author

Beliveau, Vincent ; Ozenne, Brice ; Strother, Stephen ; Greve, Douglas N. ; Svarer, Claus ; Knudsen, Gitte Moos ; Ganz, Melanie. / The structure of the serotonin system : A PET imaging study. In: NeuroImage. 2020 ; Vol. 205.

Bibtex

@article{bb99f39e79a444cf9ef0afb6d85a47ba,
title = "The structure of the serotonin system: A PET imaging study",
abstract = "The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.",
keywords = "Clustering, MRI, mRNA, PET, Serotonin, Structure",
author = "Vincent Beliveau and Brice Ozenne and Stephen Strother and Greve, {Douglas N.} and Claus Svarer and Knudsen, {Gitte Moos} and Melanie Ganz",
year = "2020",
doi = "10.1016/j.neuroimage.2019.116240",
language = "English",
volume = "205",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The structure of the serotonin system

T2 - A PET imaging study

AU - Beliveau, Vincent

AU - Ozenne, Brice

AU - Strother, Stephen

AU - Greve, Douglas N.

AU - Svarer, Claus

AU - Knudsen, Gitte Moos

AU - Ganz, Melanie

PY - 2020

Y1 - 2020

N2 - The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

AB - The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.

KW - Clustering

KW - MRI

KW - mRNA

KW - PET

KW - Serotonin

KW - Structure

UR - http://www.scopus.com/inward/record.url?scp=85073673543&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2019.116240

DO - 10.1016/j.neuroimage.2019.116240

M3 - Journal article

C2 - 31600591

AN - SCOPUS:85073673543

VL - 205

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116240

ER -

ID: 234151439