PhD defence Line Kühnel – University of Copenhagen

PhD defence Line Kühnel

Stochastic Modelling on Manifolds

Date: 18 March 2019, at 13.15

Place: Store UP1, room 5-1-02, Universitetsparken 1, 2100 København Ø

Abstract
The constant improvement of data collection techniques increases the complexity of observed data objects. Cameras and scanning technologies make it possible to retrieve detailed images of everything from microscopic structures of a cell to 3D images of anatomical objects. No matter if data are curve outlines of a shape, medical images, or a collection of landmark points for an object, such complex data structures lack vector space properties and will challenge the well-known statistical theory for data in Euclidean space. All in all, new generalised statistical methods have to be developed for analysing non-linear data samples.

This thesis presents methods for introducing uncertainty estimation in generalised statistical methods for analysing distributions of manifold-valued data objects. As closed-form expressions of probability density functions for distributions on manifolds are hard to obtain, the presented methods use stochastic theory to describe uncertainty and variation in manifold-valued data samples.
A regression model is defined which by transportation of an Euclidean semi-martingale models the relation between Euclidean covariates and a manifold-valued response. Moreover, two methods are presented for describing the uncertainty in image data. The first model separates uncertainty in images into a warp effect and a spatial intensity effect via displacement fields on a discretised lattice. The second method estimates uncertainty by stochastic deformations of images. The stochastic deformations are modelled by a stochastic flow of diffeomorphisms based on the LDDMM framework.
As a second part of the thesis, a software package primarily developed for Deep Learning tasks is used to perform concise implementation of non-linear statistical methods.

Assessment committee
Associate professor François Bernard Lauze, DIKU University of Copenhagen (Head of committee)
Professor Xavier Pennec, INRIA Sophia-Antipolis, France
Professor Le Huiling, University of Nottingham, UK

Supervisors
Associate professor Stefan Horst Sommer, DIKU, University of Copenhagen
Professor  Mads Nielsen, DIKU, University of Copenhagen

For an electronic copy of the thesis, please contact phdadmin@di.ku.dk