Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
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Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood. / Beck, Mikkel Malling; Spedden, Meaghan Elizabeth; Lundbye-Jensen, Jesper.
In: Scientific Reports, Vol. 11, 22870, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reorganization of functional and directed corticomuscular connectivity during precision grip from childhood to adulthood
AU - Beck, Mikkel Malling
AU - Spedden, Meaghan Elizabeth
AU - Lundbye-Jensen, Jesper
N1 - © 2021. The Author(s).
PY - 2021
Y1 - 2021
N2 - How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8-30 y. EEG and EMG were recorded while participants performed a uni-manual force-tracing task requiring fine control of force in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, we located and reconstructed source activity from EEG data displaying peak coherence with the EMG activity of an intrinsic hand muscle during the task. Coherent cortical sources were found anterior and posterior to the central sulcus in the contralateral hemisphere. Undirected and directed corticomuscular coherence was quantified and compared between age groups. Our results revealed that coherence was greater in adults (20-30 yo) than in children (8-10 yo) and that this difference was driven by greater magnitudes of descending (cortex-to-muscle), rather than ascending (muscle-to-cortex), coherence. We speculate that the age-related differences reflect maturation of corticomuscular networks leading to increased functional connectivity with age. We interpret the greater magnitude of descending oscillatory coupling as reflecting a greater degree of feedforward control in adults compared to children. The findings provide a detailed characterization of differences in functional sensorimotor connectivity for individuals at different stages of typical ontogenetic development that may be related to the maturational refinement of dexterous motor control.
AB - How does the neural control of fine movements develop from childhood to adulthood? Here, we investigated developmental differences in functional corticomuscular connectivity using coherence analyses in 111 individuals from four different age groups covering the age range 8-30 y. EEG and EMG were recorded while participants performed a uni-manual force-tracing task requiring fine control of force in a precision grip with both the dominant and non-dominant hand. Using beamforming methods, we located and reconstructed source activity from EEG data displaying peak coherence with the EMG activity of an intrinsic hand muscle during the task. Coherent cortical sources were found anterior and posterior to the central sulcus in the contralateral hemisphere. Undirected and directed corticomuscular coherence was quantified and compared between age groups. Our results revealed that coherence was greater in adults (20-30 yo) than in children (8-10 yo) and that this difference was driven by greater magnitudes of descending (cortex-to-muscle), rather than ascending (muscle-to-cortex), coherence. We speculate that the age-related differences reflect maturation of corticomuscular networks leading to increased functional connectivity with age. We interpret the greater magnitude of descending oscillatory coupling as reflecting a greater degree of feedforward control in adults compared to children. The findings provide a detailed characterization of differences in functional sensorimotor connectivity for individuals at different stages of typical ontogenetic development that may be related to the maturational refinement of dexterous motor control.
KW - Faculty of Science
KW - Corticomuscular coherence
KW - Age groups
KW - Adults
KW - Children
KW - Age-related differences
KW - Functional sensorimotor connectivity
KW - Dexterous motor control
U2 - 10.1038/s41598-021-01903-1
DO - 10.1038/s41598-021-01903-1
M3 - Journal article
C2 - 34819532
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 22870
ER -
ID: 285713554