Quantifying emphysema extent from weakly labeled CT scans of the lungs using label proportions learning

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Quantification of emphysema extent is important in diagnosing and monitoring patients with chronic obstructive pulmonary disease (COPD). Several studies have shown that emphysema quantification by supervised texture classification is more robust and accurate than traditional densitometry. Current techniques require highly time consuming manual annotations of patches or use only weak labels indicating overall disease status (e.g, COPD or healthy). We show how visual scoring of regional emphysema extent can be exploited in a learning with label proportions (LLP) framework to both predict presence of emphysema in smaller patches and estimate regional extent. We evaluate performance on 195 visually scored CT scans and achieve an intraclass correlation of 0.72 (0.65–0.78) between predicted region extent and expert raters. To our knowledge this is the first time that LLP methods have been applied to medical imaging data.
Original languageEnglish
Title of host publicationThe Sixth International Workshop on Pulmonary Image Analysis
EditorsReinhard R. Beichel, Keyvan Farahani, Colin Jacobs, Sven Kabus, Atilla P. Kiraly, Jan-Martin Kuhnigk, Jamie R. McClelland, Kensaku Mori, Jens Petersen, Simon Rit
Number of pages11
PublisherCreateSpace Independent Publishing Platform
Publication date2016
ISBN (Print)978-1537038582
Publication statusPublished - 2016
EventSixth International Workshop on Pulmonary Image Analysis - Athen, Greece
Duration: 21 Oct 201621 Oct 2016
Conference number: 6


ConferenceSixth International Workshop on Pulmonary Image Analysis

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