Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer

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Standard

Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer. / Wahlstedt, Isak; Andratschke, Nicolaus; Behrens, Claus P.; Ehrbar, Stefanie; Gabryś, Hubert S.; Schüler, Helena Garcia; Guckenberger, Matthias; Smith, Abraham George; Tanadini-Lang, Stephanie; Tascón-Vidarte, José D.; Vogelius, Ivan R.; van Timmeren, Janita E.

I: Radiotherapy and Oncology, Bind 170, 2022, s. 205-212.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wahlstedt, I, Andratschke, N, Behrens, CP, Ehrbar, S, Gabryś, HS, Schüler, HG, Guckenberger, M, Smith, AG, Tanadini-Lang, S, Tascón-Vidarte, JD, Vogelius, IR & van Timmeren, JE 2022, 'Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer', Radiotherapy and Oncology, bind 170, s. 205-212. https://doi.org/10.1016/j.radonc.2022.03.013

APA

Wahlstedt, I., Andratschke, N., Behrens, C. P., Ehrbar, S., Gabryś, H. S., Schüler, H. G., Guckenberger, M., Smith, A. G., Tanadini-Lang, S., Tascón-Vidarte, J. D., Vogelius, I. R., & van Timmeren, J. E. (2022). Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer. Radiotherapy and Oncology, 170, 205-212. https://doi.org/10.1016/j.radonc.2022.03.013

Vancouver

Wahlstedt I, Andratschke N, Behrens CP, Ehrbar S, Gabryś HS, Schüler HG o.a. Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer. Radiotherapy and Oncology. 2022;170:205-212. https://doi.org/10.1016/j.radonc.2022.03.013

Author

Wahlstedt, Isak ; Andratschke, Nicolaus ; Behrens, Claus P. ; Ehrbar, Stefanie ; Gabryś, Hubert S. ; Schüler, Helena Garcia ; Guckenberger, Matthias ; Smith, Abraham George ; Tanadini-Lang, Stephanie ; Tascón-Vidarte, José D. ; Vogelius, Ivan R. ; van Timmeren, Janita E. / Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer. I: Radiotherapy and Oncology. 2022 ; Bind 170. s. 205-212.

Bibtex

@article{4f6a9cdb9a7e478a96a5fa2d270fd2c0,
title = "Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer",
abstract = "Background and purpose: MR-guided radiotherapy (MRgRT) allows real-time beam-gating to compensate for intra-fractional target position variations. This study investigates the dosimetric impact of beam-gating and the impact of PTV margin on prostate coverage for prostate cancer patients treated with online-adaptive MRgRT. Materials and methods: 20 consecutive prostate cancer patients were treated with online-adaptive MRgRT SBRT with 36.25 Gy in 5 fractions (PTV D95% ≥ 95% (N = 5) and PTV D95% ≥ 100% (N = 15)). Sagittal 2D cine MRIs were used for gating on the prostate with a 3 mm expansion as the gating window. We computed motion-compensated dose distributions for (i) all prostate positions during treatment (simulating non-gated treatments) and (ii) for prostate positions within the gating window (gated treatments). To evaluate the impact of PTV margin on prostate coverage, we simulated coverage with smaller margins than clinically applied both for gated and non-gated treatments. Motion-compensated fraction doses were accumulated and dose metrics were compared. Results: We found a negligible dosimetric impact of beam-gating on prostate coverage (median of 0.00 Gy for both D95% and Dmean). For 18/20 patients, prostate coverage (D95% ≥ 100%) would have been ensured with a prostate-to-PTV margin of 3 mm, even without gating. The same was true for all but one fraction. Conclusion: Beam-gating has negligible dosimetric impact in online-adaptive MRgRT of prostate cancer. Accounting for motion, the clinically used prostate-to-PTV margin could potentially be reduced from 5 mm to 3 mm for 18/20 patients.",
keywords = "Adaptive radiotherapy, Beam-gating, Deformable image registration, Dose accumulation, Margin assessment, Motion-mitigation, MR-guided radiotherapy, Prostate cancer, Prostate motion, Radiotherapy",
author = "Isak Wahlstedt and Nicolaus Andratschke and Behrens, {Claus P.} and Stefanie Ehrbar and Gabry{\'s}, {Hubert S.} and Sch{\"u}ler, {Helena Garcia} and Matthias Guckenberger and Smith, {Abraham George} and Stephanie Tanadini-Lang and Tasc{\'o}n-Vidarte, {Jos{\'e} D.} and Vogelius, {Ivan R.} and {van Timmeren}, {Janita E.}",
note = "Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
doi = "10.1016/j.radonc.2022.03.013",
language = "English",
volume = "170",
pages = "205--212",
journal = "Radiotherapy & Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Gating has a negligible impact on dose delivered in MRI-guided online adaptive radiotherapy of prostate cancer

AU - Wahlstedt, Isak

AU - Andratschke, Nicolaus

AU - Behrens, Claus P.

AU - Ehrbar, Stefanie

AU - Gabryś, Hubert S.

AU - Schüler, Helena Garcia

AU - Guckenberger, Matthias

AU - Smith, Abraham George

AU - Tanadini-Lang, Stephanie

AU - Tascón-Vidarte, José D.

AU - Vogelius, Ivan R.

AU - van Timmeren, Janita E.

N1 - Publisher Copyright: © 2022 The Authors

PY - 2022

Y1 - 2022

N2 - Background and purpose: MR-guided radiotherapy (MRgRT) allows real-time beam-gating to compensate for intra-fractional target position variations. This study investigates the dosimetric impact of beam-gating and the impact of PTV margin on prostate coverage for prostate cancer patients treated with online-adaptive MRgRT. Materials and methods: 20 consecutive prostate cancer patients were treated with online-adaptive MRgRT SBRT with 36.25 Gy in 5 fractions (PTV D95% ≥ 95% (N = 5) and PTV D95% ≥ 100% (N = 15)). Sagittal 2D cine MRIs were used for gating on the prostate with a 3 mm expansion as the gating window. We computed motion-compensated dose distributions for (i) all prostate positions during treatment (simulating non-gated treatments) and (ii) for prostate positions within the gating window (gated treatments). To evaluate the impact of PTV margin on prostate coverage, we simulated coverage with smaller margins than clinically applied both for gated and non-gated treatments. Motion-compensated fraction doses were accumulated and dose metrics were compared. Results: We found a negligible dosimetric impact of beam-gating on prostate coverage (median of 0.00 Gy for both D95% and Dmean). For 18/20 patients, prostate coverage (D95% ≥ 100%) would have been ensured with a prostate-to-PTV margin of 3 mm, even without gating. The same was true for all but one fraction. Conclusion: Beam-gating has negligible dosimetric impact in online-adaptive MRgRT of prostate cancer. Accounting for motion, the clinically used prostate-to-PTV margin could potentially be reduced from 5 mm to 3 mm for 18/20 patients.

AB - Background and purpose: MR-guided radiotherapy (MRgRT) allows real-time beam-gating to compensate for intra-fractional target position variations. This study investigates the dosimetric impact of beam-gating and the impact of PTV margin on prostate coverage for prostate cancer patients treated with online-adaptive MRgRT. Materials and methods: 20 consecutive prostate cancer patients were treated with online-adaptive MRgRT SBRT with 36.25 Gy in 5 fractions (PTV D95% ≥ 95% (N = 5) and PTV D95% ≥ 100% (N = 15)). Sagittal 2D cine MRIs were used for gating on the prostate with a 3 mm expansion as the gating window. We computed motion-compensated dose distributions for (i) all prostate positions during treatment (simulating non-gated treatments) and (ii) for prostate positions within the gating window (gated treatments). To evaluate the impact of PTV margin on prostate coverage, we simulated coverage with smaller margins than clinically applied both for gated and non-gated treatments. Motion-compensated fraction doses were accumulated and dose metrics were compared. Results: We found a negligible dosimetric impact of beam-gating on prostate coverage (median of 0.00 Gy for both D95% and Dmean). For 18/20 patients, prostate coverage (D95% ≥ 100%) would have been ensured with a prostate-to-PTV margin of 3 mm, even without gating. The same was true for all but one fraction. Conclusion: Beam-gating has negligible dosimetric impact in online-adaptive MRgRT of prostate cancer. Accounting for motion, the clinically used prostate-to-PTV margin could potentially be reduced from 5 mm to 3 mm for 18/20 patients.

KW - Adaptive radiotherapy

KW - Beam-gating

KW - Deformable image registration

KW - Dose accumulation

KW - Margin assessment

KW - Motion-mitigation

KW - MR-guided radiotherapy

KW - Prostate cancer

KW - Prostate motion

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=85128282685&partnerID=8YFLogxK

U2 - 10.1016/j.radonc.2022.03.013

DO - 10.1016/j.radonc.2022.03.013

M3 - Journal article

C2 - 35351536

AN - SCOPUS:85128282685

VL - 170

SP - 205

EP - 212

JO - Radiotherapy & Oncology

JF - Radiotherapy & Oncology

SN - 0167-8140

ER -

ID: 307750057