Birthweight z-score and fat-free mass at birth predict body composition at 3 years in Danish children born from obese mothers
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Birthweight z-score and fat-free mass at birth predict body composition at 3 years in Danish children born from obese mothers. / Berglund, Nanna Reinholdt; Lewis, Jack Ivor; Michaelsen, Kim F.; Mølgaard, Christian; Renault, Kristina Martha; Carlsen, Eva M.
I: Acta Paediatrica, Bind 111, Nr. 7, 2022, s. 1427-1434.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Birthweight z-score and fat-free mass at birth predict body composition at 3 years in Danish children born from obese mothers
AU - Berglund, Nanna Reinholdt
AU - Lewis, Jack Ivor
AU - Michaelsen, Kim F.
AU - Mølgaard, Christian
AU - Renault, Kristina Martha
AU - Carlsen, Eva M
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Aim: We investigated associations between newborn body composition and anthropometry and body composition at 3 years in Danish children born from obese mothers.Methods: Analyses are based on data from the observational cohort study SKOT II (SKOT; small children's diet and wellbeing (Danish)). Body composition at birth and at 3 years was assessed by Dual-energy X-ray Absorptiometry (DXA) scans and bioelectrical impedance analysis (BIA), respectively. Multiple linear regression models were applied to determine associations between newborn body composition and anthropometry and body composition at 3 years.Results: Birthweight z-score (BWZ) was positively associated with fat-free mass (FFM), height, fat-free mass index (FFMI), fat mass (FM) and fat mass index (FMI) at 3 years. Newborn FFM was positively associated with FFM, height, FFMI and FM at 3 years and positive trends were seen between newborn FM and FM and FMI at 3 years.Conclusion: We showed that infants born with a higher BWZ go on to be taller at 3 years. They also grow to be heavier, to which FM and FFM both contribute, independently of linear growth. Additionally, it seems that FFM tracks into early childhood, thus supporting intrauterine programming of later health.
AB - Aim: We investigated associations between newborn body composition and anthropometry and body composition at 3 years in Danish children born from obese mothers.Methods: Analyses are based on data from the observational cohort study SKOT II (SKOT; small children's diet and wellbeing (Danish)). Body composition at birth and at 3 years was assessed by Dual-energy X-ray Absorptiometry (DXA) scans and bioelectrical impedance analysis (BIA), respectively. Multiple linear regression models were applied to determine associations between newborn body composition and anthropometry and body composition at 3 years.Results: Birthweight z-score (BWZ) was positively associated with fat-free mass (FFM), height, fat-free mass index (FFMI), fat mass (FM) and fat mass index (FMI) at 3 years. Newborn FFM was positively associated with FFM, height, FFMI and FM at 3 years and positive trends were seen between newborn FM and FM and FMI at 3 years.Conclusion: We showed that infants born with a higher BWZ go on to be taller at 3 years. They also grow to be heavier, to which FM and FFM both contribute, independently of linear growth. Additionally, it seems that FFM tracks into early childhood, thus supporting intrauterine programming of later health.
KW - Faculty of Science
KW - Maternal obesity
KW - Offspring body composition
KW - Fat mass
KW - Fat-free mass
KW - Dual-energy X-ray absorptiometry
KW - Bioelectrical impedance analysis
U2 - 10.1111/apa.16346
DO - 10.1111/apa.16346
M3 - Journal article
C2 - 35357724
VL - 111
SP - 1427
EP - 1434
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 7
ER -
ID: 301807438