TY - JOUR

T1 - Changes in circulating metabolites during weight loss and weight loss maintenance in relation to cardiometabolic risk

AU - Papandreou, Christopher

AU - Harrold, Joanne A

AU - Hansen, Thea Toft

AU - Halford, Jason C G

AU - Sjödin, Anders Mikael

AU - Bulló, Mònica

N1 - CURIS 2021 NEXS 388

PY - 2021

Y1 - 2021

N2 - Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ≥8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C.

AB - Background: There is a substantial lack of knowledge of the biochemical mechanisms by which weight loss and weight regain exert their beneficial and adverse effects, respectively, on cardiometabolic outcomes. We examined associations between changes in circulating metabolites and changes in cardiometabolic risk factors during diet-induced weight loss and weight loss maintenance. Methods: This prospective analysis of data from the Satiety Innovation (SATIN) study involved adults living with overweight and obesity (mean age=47.5). One hundred sixty-two subjects achieving ≥8% weight loss during an initial 8-week low-calorie diet (LCD) were included in a 12-week weight loss maintenance period. Circulating metabolites (m=123) were profiled using a targeted multiplatform approach. Data were analyzed using multivariate linear regression models. Results: Decreases in the concentrations of several phosphatidylcholines (PCs), sphingomyelins (SMs), and valine were consistently associated with decreases in total (TChol) and low-density lipoprotein cholesterol (LDL-C) levels during the LCD. Increases in PCs and SMs were significantly associated with increases in TChol and LDL-C during the weight loss maintenance period. Decreases and increases in PCs during LCD and maintenance period, respectively, were associated with decreases in the levels of triglycerides. Conclusions: The results of this study suggest that decreases in circulating PCs and SMs during weight loss and the subsequent weight loss maintenance period may decrease the cardiovascular risk through impacting TChol and LDL-C.

KW - Adult

KW - Aged

KW - Body Mass Index

KW - Body Weight Maintenance/physiology

KW - Caloric Restriction

KW - Cardiometabolic Risk Factors

KW - Cholesterol/blood

KW - Cholesterol, LDL/blood

KW - Female

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Obesity/blood

KW - Phosphatidylcholines/blood

KW - Prospective Studies

KW - Satiation

KW - Sphingomyelins/blood

KW - Triglycerides/blood

KW - Valine/blood

KW - Weight Loss/physiology

KW - Young Adult

KW - Faculty of Science

KW - Metabolomics

KW - Cardiometabolic risk

KW - Weight loss

KW - Weight maintenance

KW - SATIN

U2 - 10.3390/nu13124289

DO - 10.3390/nu13124289

M3 - Journal article

C2 - 34959840

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 12

M1 - 4289

ER -