EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis

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Standard

EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. / Hidalgo, Daniel; Bejder, Jacob; Pop, Ramona; Gellatly, Kyle; Hwang, Yung; Scalf, S Maxwell; Eastman, Anna E; Chen, Jane-Jane; Zhu, Lihua Julie; Heuberger, Jules A A C; Guo, Shangqin; Koury, Mark J; Nordsborg, Nikolai Baastrup; Socolovsky, Merav.

I: Nature Communications, Bind 12, 7334, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hidalgo, D, Bejder, J, Pop, R, Gellatly, K, Hwang, Y, Scalf, SM, Eastman, AE, Chen, J-J, Zhu, LJ, Heuberger, JAAC, Guo, S, Koury, MJ, Nordsborg, NB & Socolovsky, M 2021, 'EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis', Nature Communications, bind 12, 7334. https://doi.org/10.1038/s41467-021-27562-4

APA

Hidalgo, D., Bejder, J., Pop, R., Gellatly, K., Hwang, Y., Scalf, S. M., Eastman, A. E., Chen, J-J., Zhu, L. J., Heuberger, J. A. A. C., Guo, S., Koury, M. J., Nordsborg, N. B., & Socolovsky, M. (2021). EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications, 12, [7334]. https://doi.org/10.1038/s41467-021-27562-4

Vancouver

Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Scalf SM o.a. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications. 2021;12. 7334. https://doi.org/10.1038/s41467-021-27562-4

Author

Hidalgo, Daniel ; Bejder, Jacob ; Pop, Ramona ; Gellatly, Kyle ; Hwang, Yung ; Scalf, S Maxwell ; Eastman, Anna E ; Chen, Jane-Jane ; Zhu, Lihua Julie ; Heuberger, Jules A A C ; Guo, Shangqin ; Koury, Mark J ; Nordsborg, Nikolai Baastrup ; Socolovsky, Merav. / EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. I: Nature Communications. 2021 ; Bind 12.

Bibtex

@article{2534228ffbaf4558bcac94ea6f42a23c,
title = "EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis",
abstract = "The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor-/- mouse erythroblasts endowed with survival signaling to identify novel non-redundant EpoR functions. We find that, paradoxically, EpoR signaling increases red cell size while also increasing the number and speed of erythroblast cell cycles. EpoR-regulation of cell size is independent of established red cell size regulation by iron. High erythropoietin (Epo) increases red cell size in wild-type mice and in human volunteers. The increase in mean corpuscular volume (MCV) outlasts the duration of Epo treatment and is not the result of increased reticulocyte number. Our work shows that EpoR signaling alters the relationship between cycling and cell size. Further, diagnostic interpretations of increased MCV should now include high Epo levels and hypoxic stress.",
keywords = "Faculty of Science, Erythropoietin receptor, EpoR, EpoR signaling, Mean corpuscular volume (MCV)",
author = "Daniel Hidalgo and Jacob Bejder and Ramona Pop and Kyle Gellatly and Yung Hwang and Scalf, {S Maxwell} and Eastman, {Anna E} and Jane-Jane Chen and Zhu, {Lihua Julie} and Heuberger, {Jules A A C} and Shangqin Guo and Koury, {Mark J} and Nordsborg, {Nikolai Baastrup} and Merav Socolovsky",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
doi = "10.1038/s41467-021-27562-4",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis

AU - Hidalgo, Daniel

AU - Bejder, Jacob

AU - Pop, Ramona

AU - Gellatly, Kyle

AU - Hwang, Yung

AU - Scalf, S Maxwell

AU - Eastman, Anna E

AU - Chen, Jane-Jane

AU - Zhu, Lihua Julie

AU - Heuberger, Jules A A C

AU - Guo, Shangqin

AU - Koury, Mark J

AU - Nordsborg, Nikolai Baastrup

AU - Socolovsky, Merav

N1 - © 2021. The Author(s).

PY - 2021

Y1 - 2021

N2 - The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor-/- mouse erythroblasts endowed with survival signaling to identify novel non-redundant EpoR functions. We find that, paradoxically, EpoR signaling increases red cell size while also increasing the number and speed of erythroblast cell cycles. EpoR-regulation of cell size is independent of established red cell size regulation by iron. High erythropoietin (Epo) increases red cell size in wild-type mice and in human volunteers. The increase in mean corpuscular volume (MCV) outlasts the duration of Epo treatment and is not the result of increased reticulocyte number. Our work shows that EpoR signaling alters the relationship between cycling and cell size. Further, diagnostic interpretations of increased MCV should now include high Epo levels and hypoxic stress.

AB - The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR) is essential for erythroblast survival, but its other functions are not well characterized. Here we use Epor-/- mouse erythroblasts endowed with survival signaling to identify novel non-redundant EpoR functions. We find that, paradoxically, EpoR signaling increases red cell size while also increasing the number and speed of erythroblast cell cycles. EpoR-regulation of cell size is independent of established red cell size regulation by iron. High erythropoietin (Epo) increases red cell size in wild-type mice and in human volunteers. The increase in mean corpuscular volume (MCV) outlasts the duration of Epo treatment and is not the result of increased reticulocyte number. Our work shows that EpoR signaling alters the relationship between cycling and cell size. Further, diagnostic interpretations of increased MCV should now include high Epo levels and hypoxic stress.

KW - Faculty of Science

KW - Erythropoietin receptor

KW - EpoR

KW - EpoR signaling

KW - Mean corpuscular volume (MCV)

U2 - 10.1038/s41467-021-27562-4

DO - 10.1038/s41467-021-27562-4

M3 - Journal article

C2 - 34921133

VL - 12

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7334

ER -

ID: 287691579