Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk
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Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk. / Hulman, Adam; Simmons, Rebecca Kate; Vistisen, Dorte; Tabák, Adam G; Dekker, Jacqueline M; Alssema, Marjan; Rutters, Femke; Koopman, Anitra D M; Solomon, Thomas P J; Kirwan, John P; Hansen, Torben; Jonsson, Anna Elisabet; Gjesing, Anette Marianne Prior; Eiberg, Hans Rudolf Lytchoff; Astrup, Arne; Pedersen, Oluf Borbye; Sørensen, Thorkild I.A.; Witte, Daniel; Færch, Kristine.
I: Endocrine, Bind 55, Nr. 2, 2017, s. 427-434.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk
AU - Hulman, Adam
AU - Simmons, Rebecca Kate
AU - Vistisen, Dorte
AU - Tabák, Adam G
AU - Dekker, Jacqueline M
AU - Alssema, Marjan
AU - Rutters, Femke
AU - Koopman, Anitra D M
AU - Solomon, Thomas P J
AU - Kirwan, John P
AU - Hansen, Torben
AU - Jonsson, Anna Elisabet
AU - Gjesing, Anette Marianne Prior
AU - Eiberg, Hans Rudolf Lytchoff
AU - Astrup, Arne
AU - Pedersen, Oluf Borbye
AU - Sørensen, Thorkild I.A.
AU - Witte, Daniel
AU - Færch, Kristine
N1 - CURIS 2017 NEXS 042
PY - 2017
Y1 - 2017
N2 - We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups.We analyzed data from 1,267 individuals without diabetes from five studies in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test,resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic riskfactor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak times varied greatly between groups, ranging from 7–12 mmol/L, and 35–70 min. The group with the lowest and earliest plasma glucose peak had the lowest estimated cardiovascular risk, while the group with the most delayed plasma glucose peak and the highest 2-h value had the highest estimated risk. One group, with normal fasting and 2-h values, exhibited an unusual profile, with the highest glucose peak and the highest proportion of smokers and men. The heterogeneity in glucose response curves and the distinct cardiometabolic risk profiles may reflect different underlying physiologies. Our results warrant more detailed studies to identify the source of the heterogeneity across the different phenotypes and whether these differences play a role in the development of type 2 diabetes and cardiovascular disease.
AB - We aimed to examine heterogeneity in glucose response curves during an oral glucose tolerance test with multiple measurements and to compare cardiometabolic risk profiles between identified glucose response curve groups.We analyzed data from 1,267 individuals without diabetes from five studies in Denmark, the Netherlands and the USA. Each study included between 5 and 11 measurements at different time points during a 2-h oral glucose tolerance test,resulting in 9,602 plasma glucose measurements. Latent class trajectories with a cubic specification for time were fitted to identify different patterns of plasma glucose change during the oral glucose tolerance test. Cardiometabolic riskfactor profiles were compared between the identified groups. Using latent class trajectory analysis, five glucose response curves were identified. Despite similar fasting and 2-h values, glucose peaks and peak times varied greatly between groups, ranging from 7–12 mmol/L, and 35–70 min. The group with the lowest and earliest plasma glucose peak had the lowest estimated cardiovascular risk, while the group with the most delayed plasma glucose peak and the highest 2-h value had the highest estimated risk. One group, with normal fasting and 2-h values, exhibited an unusual profile, with the highest glucose peak and the highest proportion of smokers and men. The heterogeneity in glucose response curves and the distinct cardiometabolic risk profiles may reflect different underlying physiologies. Our results warrant more detailed studies to identify the source of the heterogeneity across the different phenotypes and whether these differences play a role in the development of type 2 diabetes and cardiovascular disease.
KW - Faculty of Science
KW - Oral glucose tolerance test
KW - Glucose response curve
KW - Cardiometabolic risk
KW - Latent class trajectory analysis
U2 - 10.1007/s12020-016-1126-z
DO - 10.1007/s12020-016-1126-z
M3 - Journal article
C2 - 27699707
VL - 55
SP - 427
EP - 434
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 2
ER -
ID: 166662524