Impact of timing of PERT on gastrointestinal symptoms in Danish children and adolescents with CF
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Impact of timing of PERT on gastrointestinal symptoms in Danish children and adolescents with CF. / Raun, Anne Mette Terp; Brekke, Ghita; Mølgaard, Christian; Jaudszus, Anke; G Mainz, Jochen; Pressler, Tacjana; Skov, Marianne.
I: Acta Paediatrica, Bind 111, Nr. 2, 2022, s. 432-439.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of timing of PERT on gastrointestinal symptoms in Danish children and adolescents with CF
AU - Raun, Anne Mette Terp
AU - Brekke, Ghita
AU - Mølgaard, Christian
AU - Jaudszus, Anke
AU - G Mainz, Jochen
AU - Pressler, Tacjana
AU - Skov, Marianne
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Aim: Gastrointestinal (GI) symptoms are often reported by CF-patients. Despite a proven relation to exocrine pancreatic insufficiency (PI), it remains unclear whether GI symptoms are related to the timing of pancreatic enzyme replacement therapy (PERT). Whereas most international recommendations suggest administration of PERT at the beginning of meals, it has not been studied whether such a proceeding is associated with lower burden of symptoms.Methods: Thirty CF patients aged 0-17 years of age with PI were randomized to four weeks of PERT prior to meals followed by four weeks of PERT after meals or vice versa. Using the CF-specific validated CFAbd-Score, abdominal pain, dysfunctional bowel habits and Quality of Life (QoL) related to GI symptoms were assessed in relation to the timing of PERT. Data was analyzed using a linear mixed model.Results: There was no significant difference regarding abdominal pain, bowel habits or QoL related to GI symptoms when timing of PERT was changed from prior to after meals.Conclusion: No significant difference was found when administration mode of PERT changed from prior to after meals or vice versa. However, after an individual assessment, some patients may profit from changing administration mode of PERT from prior to after meals.
AB - Aim: Gastrointestinal (GI) symptoms are often reported by CF-patients. Despite a proven relation to exocrine pancreatic insufficiency (PI), it remains unclear whether GI symptoms are related to the timing of pancreatic enzyme replacement therapy (PERT). Whereas most international recommendations suggest administration of PERT at the beginning of meals, it has not been studied whether such a proceeding is associated with lower burden of symptoms.Methods: Thirty CF patients aged 0-17 years of age with PI were randomized to four weeks of PERT prior to meals followed by four weeks of PERT after meals or vice versa. Using the CF-specific validated CFAbd-Score, abdominal pain, dysfunctional bowel habits and Quality of Life (QoL) related to GI symptoms were assessed in relation to the timing of PERT. Data was analyzed using a linear mixed model.Results: There was no significant difference regarding abdominal pain, bowel habits or QoL related to GI symptoms when timing of PERT was changed from prior to after meals.Conclusion: No significant difference was found when administration mode of PERT changed from prior to after meals or vice versa. However, after an individual assessment, some patients may profit from changing administration mode of PERT from prior to after meals.
KW - Faculty of Science
KW - Cystic fibrosis (CF)
KW - CFAbd-Score
KW - Enzyme supplementation
KW - Gastrointestinal symptoms
KW - Pancreatic insufficiency
U2 - 10.1111/apa.16143
DO - 10.1111/apa.16143
M3 - Journal article
C2 - 34626004
VL - 111
SP - 432
EP - 439
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 2
ER -
ID: 281597054