TY - JOUR

T1 - Monomethyl branched-chain fatty acids: Health effects and biological mechanisms

AU - Gozdzik, Paulina

AU - Magkos, Faidon

AU - Sledzinski, Tomasz

AU - Mika, Adriana

N1 - Copyright © 2023. Published by Elsevier Ltd.

PY - 2023

Y1 - 2023

N2 - Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of their effects on human health. Recently, they have been gaining interest, especially in relation to various human diseases. This review describes the occurrence of BCFA, their dietary sources, their potential health effects, and the current state of knowledge concerning their mechanism(s) of action. Many studies have been conducted so far in cellular and animal models, which reveal potent anti-cancer, lipid lowering, anti-inflammatory and neuroprotective actions. Research in humans is scarce. Therefore, further studies on animals and humans should be performed to confirm and expand these findings, and improve our understanding of the potential relevance of BCFA to human health and disease.

AB - Branched-chain fatty acids (BCFA) are a group of lipids that are widely present in various organisms; they take part in numerous biochemical processes and affect multiple signaling pathways. However, BCFA are not well explored in terms of their effects on human health. Recently, they have been gaining interest, especially in relation to various human diseases. This review describes the occurrence of BCFA, their dietary sources, their potential health effects, and the current state of knowledge concerning their mechanism(s) of action. Many studies have been conducted so far in cellular and animal models, which reveal potent anti-cancer, lipid lowering, anti-inflammatory and neuroprotective actions. Research in humans is scarce. Therefore, further studies on animals and humans should be performed to confirm and expand these findings, and improve our understanding of the potential relevance of BCFA to human health and disease.

KW - Faculty of Science

KW - Branched-chain fatty acids

KW - Nutrition

KW - Anti-cancer properties

KW - Lipid metabolism

KW - Inflammation

U2 - 10.1016/j.plipres.2023.101226

DO - 10.1016/j.plipres.2023.101226

M3 - Review

C2 - 37094753

VL - 90

JO - Progress in Lipid Research

JF - Progress in Lipid Research

SN - 0163-7827

M1 - 101226

ER -