Supervised hub-detection for brain connectivity

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

Niklas Kasenburg, Matthew George Liptrot, Nina Linde Reislev, Ellen Garde, Mads Nielsen, Aasa Feragen

A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied, but can smooth discriminative signals in the population, degrading predictive performance. We present a novel hub-detection optimized for supervised learning that both clusters network nodes based on population level variation in connectivity and also takes the learning problem into account. The found hubs are a low-dimensional representation of the network and are chosen based on predictive performance as features for a linear regression. We apply our method to the problem of finding age-related changes in structural connectivity. We compare our supervised hub-detection (SHD) to an unsupervised hub-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any network regression problem. Further development of the presented algorithm will be the extension to other predictive models such as classification or non-linear regression. textcopyright (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
OriginalsprogEngelsk
TitelMedical Imaging 2016 : Image Processing
RedaktørerMartin A. Styner, Elsa D. Angelini
Antal sider9
ForlagSPIE - International Society for Optical Engineering
Publikationsdato2016
Artikelnummer978409
ISBN (Trykt)978-1-51060-019-5
DOI
StatusUdgivet - 2016
BegivenhedSPIE Medical Imaging 2016 - San Diego, Cal., USA
Varighed: 27 feb. 20163 mar. 2016

Konference

KonferenceSPIE Medical Imaging 2016
LandUSA
BySan Diego, Cal.
Periode27/02/201603/03/2016
NavnProgress in Biomedical Optics and Imaging
Nummer39
Vol/bind17
ISSN1605-7422

ID: 160636311