Weight preserving image registration for monitoring disease progression in lung CT.

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

We present a new image registration based method for monitoring regional disease progression in longitudinal image studies of lung disease. A free-form image registration technique is used to match a baseline 3D CT lung scan onto a following scan. Areas with lower intensity in the following scan compared with intensities in the deformed baseline image indicate local loss of lung tissue that is associated with progression of emphysema. To account for differences in lung intensity owing to differences in the inspiration level in the two scans rather than disease progression, we propose to adjust the density of lung tissue with respect to local expansion or compression such that the total weight of the lungs is preserved during deformation. Our method provides a good estimation of regional destruction of lung tissue for subjects with a significant difference in inspiration level between CT scans and may result in a more sensitive measure of disease progression than standard quantitative CT measures.
TitelMecical Image Computing and Computer-Assisted Intervention - MICCAI 2008 : 11th International Conference, New York, NY, USA, September 6-10, 2008, proceedings, Part II
RedaktørerD. Metaxas, L. Axel, G. Fichtinger, G. Szekely
Antal sider8
ISBN (Trykt)978-3-540-85989-5
StatusUdgivet - 2008
BegivenhedInternational Conference on Medical Image Computing and Computer-Assisted Intervention - New York, NY, USA
Varighed: 6 sep. 200810 sep. 2008
Konferencens nummer: 11


KonferenceInternational Conference on Medical Image Computing and Computer-Assisted Intervention
ByNew York, NY
NavnLecture notes in computer science

ID: 9092094