Synchrotron radiation μCT and histology evaluation of bone-to-implant contact
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Synchrotron radiation μCT and histology evaluation of bone-to-implant contact. / Neldam, Camilla Albeck; Sporring, Jon; Rack, Alexander; Lauridsen, Torsten; Hauge, Ellen Margrethe; Jørgensen, Henrik L.; Jørgensen, Niklas Rye; Feidenhans'l, Robert Krarup; Pinholt, Else Marie.
I: Journal of Cranio-Maxillofacial Surgery, Bind 45, Nr. 9, 09.2017, s. 1448-1457.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Synchrotron radiation μCT and histology evaluation of bone-to-implant contact
AU - Neldam, Camilla Albeck
AU - Sporring, Jon
AU - Rack, Alexander
AU - Lauridsen, Torsten
AU - Hauge, Ellen Margrethe
AU - Jørgensen, Henrik L.
AU - Jørgensen, Niklas Rye
AU - Feidenhans'l, Robert Krarup
AU - Pinholt, Else Marie
PY - 2017/9
Y1 - 2017/9
N2 - The purpose of this study was to evaluate bone-to-implant contact (BIC) in two-dimensional (2D) histology compared to high-resolution three-dimensional (3D) synchrotron radiation micro computed tomography (SR micro-CT). High spatial resolution, excellent signal-to-noise ratio, and contrast establish SR micro-CT as the leading imaging modality for hard X-ray microtomography. Using SR micro-CT at voxel size 5 μm in an experimental goat mandible model, no statistically significant difference was found between the different treatment modalities nor between recipient and reconstructed bone. The histological evaluation showed a statistically significant difference between BIC in reconstructed and recipient bone (p < 0.0001). Further, no statistically significant difference was found between the different treatment modalities which we found was due to large variation and subsequently due to low power. Comparing histology and SR micro-CT evaluation a bias of 5.2% was found in reconstructed area, and 15.3% in recipient bone. We conclude that for evaluation of BIC with histology and SR micro-CT, SR micro-CT cannot be proven more precise than histology for evaluation of BIC, however, with this SR micro-CT method, one histologic bone section is comparable to the 3D evaluation. Further, the two methods complement each other with knowledge on BIC in 2D and 3D.
AB - The purpose of this study was to evaluate bone-to-implant contact (BIC) in two-dimensional (2D) histology compared to high-resolution three-dimensional (3D) synchrotron radiation micro computed tomography (SR micro-CT). High spatial resolution, excellent signal-to-noise ratio, and contrast establish SR micro-CT as the leading imaging modality for hard X-ray microtomography. Using SR micro-CT at voxel size 5 μm in an experimental goat mandible model, no statistically significant difference was found between the different treatment modalities nor between recipient and reconstructed bone. The histological evaluation showed a statistically significant difference between BIC in reconstructed and recipient bone (p < 0.0001). Further, no statistically significant difference was found between the different treatment modalities which we found was due to large variation and subsequently due to low power. Comparing histology and SR micro-CT evaluation a bias of 5.2% was found in reconstructed area, and 15.3% in recipient bone. We conclude that for evaluation of BIC with histology and SR micro-CT, SR micro-CT cannot be proven more precise than histology for evaluation of BIC, however, with this SR micro-CT method, one histologic bone section is comparable to the 3D evaluation. Further, the two methods complement each other with knowledge on BIC in 2D and 3D.
U2 - 10.1016/j.jcms.2017.05.019
DO - 10.1016/j.jcms.2017.05.019
M3 - Journal article
C2 - 28693947
VL - 45
SP - 1448
EP - 1457
JO - Journal of Cranio-Maxillo-Facial Surgery
JF - Journal of Cranio-Maxillo-Facial Surgery
SN - 1010-5182
IS - 9
ER -
ID: 182150599