Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain
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Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain. / Hansen, Justine Y.; Markello, Ross D.; Tuominen, Lauri; Norgaard, Martin; Kuzmin, Elena; Palomero-Gallagher, Nicola; Dagher, Alain; Misic, Bratislav.
In: NeuroImage, Vol. 264, 119671, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain
AU - Hansen, Justine Y.
AU - Markello, Ross D.
AU - Tuominen, Lauri
AU - Norgaard, Martin
AU - Kuzmin, Elena
AU - Palomero-Gallagher, Nicola
AU - Dagher, Alain
AU - Misic, Bratislav
PY - 2022
Y1 - 2022
N2 - Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT1A, CB1, D-2, and MOR). These expression-density associations are related to gene differential stability and can vary between cortical and subcortical structures. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function.
AB - Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcripts is often used as a proxy for receptor densities. In the present report, we comprehensively test the spatial correlation between gene expression and protein density for a total of 27 neurotransmitter receptors, receptor binding-sites, and transporters across 9 different neurotransmitter systems, using both PET and autoradiography radioligand-based imaging modalities. We find poor spatial correspondences between gene expression and density for all neurotransmitter receptors and transporters except four single-protein metabotropic receptors (5-HT1A, CB1, D-2, and MOR). These expression-density associations are related to gene differential stability and can vary between cortical and subcortical structures. Altogether, we recommend using direct measures of receptor and transporter density when relating neurotransmitter systems to brain structure and function.
KW - HUMAN CEREBRAL-CORTEX
KW - HUMAN CONNECTOME
KW - SEROTONERGIC SYSTEM
KW - PROTEIN-SYNTHESIS
KW - PET
KW - RNA
KW - QUANTIFICATION
KW - ACETYLCHOLINE
KW - CONNECTIVITY
KW - RADIOLIGAND
U2 - 10.1016/j.neuroimage.2022.119671
DO - 10.1016/j.neuroimage.2022.119671
M3 - Journal article
C2 - 36209794
VL - 264
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
M1 - 119671
ER -
ID: 341009077