Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis: Journal of Infectious Diseases
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Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis : Journal of Infectious Diseases. / Brandt, C.T.; Holm, D.; Liptrot, Matthew George; Østergaard, C.; Lundgren, J.D.; Frimodt-Møller, N.; Skovsted, I.C.; Rowland, I.J.
I: J. Infect. Dis., Bind 197, Nr. 2, 2008, s. 235-244.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis
T2 - Journal of Infectious Diseases
AU - Brandt, C.T.
AU - Holm, D.
AU - Liptrot, Matthew George
AU - Østergaard, C.
AU - Lundgren, J.D.
AU - Frimodt-Møller, N.
AU - Skovsted, I.C.
AU - Rowland, I.J.
PY - 2008
Y1 - 2008
N2 - Background. Bacteremia plays a major role in the outcome of pneumococcal meningitis. This experimental study investigated how bacteremia influences the pathophysiologic profile of the brain. Methods. Rats with Streptococcus pneumoniae meningitis were randomized to 1 of 3 groups of infected study rats: (1) rats with attenuated bacteremia resulting from intravenous injection of serotype-specific pneumococcal antibody, (2) rats with early-onset bacteremia resulting from concomitant intravenous infection, or (3) a meningitis control group. The blood-brain barrier (BBB) breakdown, ventricle size, brain water distribution, and brain pathologic findings were analyzed using magnetic resonance morphological and functional imaging. Laboratory data and clinical disease scores were obtained. Results. Attenuation of the bacteremic component of pneumococcal meningitis improved clinical disease symptoms and significantly reduced ventricle expansion and BBB breakdown (P <.05). Early-onset bacteremia did not further increase ventricle size or BBB leakage. Significantly increased brain edema developed among rats with both attenuated and early-onset bacteremia (P <.05). Focal brain pathologic findings were unaffected by bacteremia and were found to be associated with cerebrospinal fluid inflammation. Conclusion. Although brain lesions appear to result from local meningeal infection, systemic infection significantly contributes to clinical disease presentation and the pathophysiology of BBB breakdown and ventricle expansion. The different end points affected by the systemic and local infectious processes should be addressed in future studies. © 2008 by the Infectious Diseases Society of America. All rights reserved.
AB - Background. Bacteremia plays a major role in the outcome of pneumococcal meningitis. This experimental study investigated how bacteremia influences the pathophysiologic profile of the brain. Methods. Rats with Streptococcus pneumoniae meningitis were randomized to 1 of 3 groups of infected study rats: (1) rats with attenuated bacteremia resulting from intravenous injection of serotype-specific pneumococcal antibody, (2) rats with early-onset bacteremia resulting from concomitant intravenous infection, or (3) a meningitis control group. The blood-brain barrier (BBB) breakdown, ventricle size, brain water distribution, and brain pathologic findings were analyzed using magnetic resonance morphological and functional imaging. Laboratory data and clinical disease scores were obtained. Results. Attenuation of the bacteremic component of pneumococcal meningitis improved clinical disease symptoms and significantly reduced ventricle expansion and BBB breakdown (P <.05). Early-onset bacteremia did not further increase ventricle size or BBB leakage. Significantly increased brain edema developed among rats with both attenuated and early-onset bacteremia (P <.05). Focal brain pathologic findings were unaffected by bacteremia and were found to be associated with cerebrospinal fluid inflammation. Conclusion. Although brain lesions appear to result from local meningeal infection, systemic infection significantly contributes to clinical disease presentation and the pathophysiology of BBB breakdown and ventricle expansion. The different end points affected by the systemic and local infectious processes should be addressed in future studies. © 2008 by the Infectious Diseases Society of America. All rights reserved.
KW - antibody
KW - pneumococcal antibody
KW - unclassified drug
KW - animal experiment
KW - animal model
KW - animal tissue
KW - article
KW - bacteremia
KW - bacterial meningitis
KW - blood brain barrier
KW - brain
KW - brain edema
KW - brain ventricle
KW - cerebrospinal fluid
KW - concurrent infection
KW - controlled study
KW - experimental infection
KW - laboratory test
KW - male
KW - nonhuman
KW - nuclear magnetic resonance
KW - pathogenesis
KW - priority journal
KW - rat
KW - serotyping
KW - statistical significance
KW - animal
KW - blood
KW - hospitalization
KW - human
KW - immunology
KW - inflammation
KW - isolation and purification
KW - microbiology
KW - motor performance
KW - nuclear magnetic resonance imaging
KW - pathogenicity
KW - pathology
KW - pathophysiology
KW - Streptococcus pneumoniae
KW - Wistar rat
KW - Animals
KW - Bacteremia
KW - Blood
KW - Blood-Brain Barrier
KW - Brain
KW - Brain Edema
KW - Cerebrospinal Fluid
KW - Humans
KW - Inflammation
KW - Magnetic Resonance Imaging
KW - Male
KW - Meningitis, Pneumococcal
KW - Motor Skills
KW - Rats
KW - Rats, Wistar
KW - Severity of Illness Index
U2 - 10.1086/524874
DO - 10.1086/524874
M3 - Journal article
C2 - 18173365
VL - 197
SP - 235
EP - 244
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -
ID: 137009270