This paper introduces a comprehensive approach for segmenting regions of interest (ROI) in diverse medical imaging datasets, encompassing ultrasound, CT scans, and X-ray images. The proposed method harnesses the capabilities of the YOLOv8 model for approximate boundary box detection across modalities, alongside the Segment Anything Model (SAM) and High Quality (HQ) SAM for fully automatic and precise segmentation. To generate boundary boxes, the YOLOv8 model was trained using a limited set of 100 images and masks from each modality.The results obtained from our approach are extensively computed and analyzed, demonstrating its effectiveness and potential in medical image analysis. Various evaluation metrics, including precision, recall, F1 score, and Dice Score, were employed to quantify the accuracy of the segmentation results. A comparative analysis was conducted to assess the individual and combined performance of the YOLOv8, YOLOv8+SAM, and YOLOv8+HQ-SAM models.The results indicate that the SAM model performs better than the other two models, exhibiting higher segmentation accuracy and overall performance. While HQ-SAM offers potential advantages, its incremental gains over the standard SAM model may not justify the additional computational cost. The YOLOv8+SAM model shows promise for enhancing medical image segmentation and its clinical implications.