Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year: a longitudinal analysis from Osteoarthritis Initiative
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Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year : a longitudinal analysis from Osteoarthritis Initiative. / Pishgar, Farhad; Ashraf-Ganjouei, Amir; Dolatshahi, Mahsa; Guermazi, Ali; Zikria, Bashir; Cao, Xu; Wan, Mei; Roemer, Frank W; Dam, Erik; Demehri, Shadpour.
In: Skeletal Radiology, Vol. 51, 2022, p. 1959–1966.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Conventional MRI-derived subchondral trabecular biomarkers and their association with knee cartilage volume loss as early as 1 year
T2 - a longitudinal analysis from Osteoarthritis Initiative
AU - Pishgar, Farhad
AU - Ashraf-Ganjouei, Amir
AU - Dolatshahi, Mahsa
AU - Guermazi, Ali
AU - Zikria, Bashir
AU - Cao, Xu
AU - Wan, Mei
AU - Roemer, Frank W
AU - Dam, Erik
AU - Demehri, Shadpour
N1 - © 2022. The Author(s), under exclusive licence to International Skeletal Society (ISS).
PY - 2022
Y1 - 2022
N2 - OBJECTIVE: To study associations between MRI-derived subchondral trabecular biomarkers obtained from conventional MRI sequences and knee cartilage loss over 12 and 24 months, using the FNIH osteoarthritis (OA) biomarkers consortium.MATERIALS AND METHODS: Data of the 600 subjects in the FNIH OA biomarkers consortium (a nested case-control study within Osteoarthritis Initiative [OAI]) were extracted from the online database. Baseline knee MRI (intermediate-weighted (IW) sequences) were evaluated to determine conventional MRI-derived trabecular thickness (cTbTh) and bone-to-total ratio (cBV/TV). The measurements for medial and lateral volumes of cartilages using baseline, 12-, and 24-month knee MRI were extracted from the OAI database, and cartilage volume loss over 12 and 24 months of follow-up were determined using Relative Change Index. The association between conventional MRI-based subchondral trabecular biomarkers and cartilage volume loss were studied using logistic regression models, adjusted for relevant confounders including age, sex, body mass index (BMI), vitamin D use, Kellgren Lawrence grade (KLG), and tibiofemoral alignment.RESULTS: Higher medial cTbTh and cBV/TV at baseline were associated with increased odds of medial tibial cartilage volume loss over 12 months (ORs: 1.01 [1.00-1.02] and 1.24 [1.10-1.39] per 1-SD change) and 24 months (ORs: 1.01 [1.00-1.02] and 1.22 [1.08-1.37], per 1-SD change). No significant association was observed between medial subchondral trabecular biomarkers and lateral tibial or femoral (medial or lateral) cartilage volume loss over the first and second follow-up years.CONCLUSIONS: Conventional MRI-derived subchondral trabecular biomarkers (higher medial cTbTh and cBV/TV) may be associated with increased medial tibial cartilage volume loss as early as 1 year.
AB - OBJECTIVE: To study associations between MRI-derived subchondral trabecular biomarkers obtained from conventional MRI sequences and knee cartilage loss over 12 and 24 months, using the FNIH osteoarthritis (OA) biomarkers consortium.MATERIALS AND METHODS: Data of the 600 subjects in the FNIH OA biomarkers consortium (a nested case-control study within Osteoarthritis Initiative [OAI]) were extracted from the online database. Baseline knee MRI (intermediate-weighted (IW) sequences) were evaluated to determine conventional MRI-derived trabecular thickness (cTbTh) and bone-to-total ratio (cBV/TV). The measurements for medial and lateral volumes of cartilages using baseline, 12-, and 24-month knee MRI were extracted from the OAI database, and cartilage volume loss over 12 and 24 months of follow-up were determined using Relative Change Index. The association between conventional MRI-based subchondral trabecular biomarkers and cartilage volume loss were studied using logistic regression models, adjusted for relevant confounders including age, sex, body mass index (BMI), vitamin D use, Kellgren Lawrence grade (KLG), and tibiofemoral alignment.RESULTS: Higher medial cTbTh and cBV/TV at baseline were associated with increased odds of medial tibial cartilage volume loss over 12 months (ORs: 1.01 [1.00-1.02] and 1.24 [1.10-1.39] per 1-SD change) and 24 months (ORs: 1.01 [1.00-1.02] and 1.22 [1.08-1.37], per 1-SD change). No significant association was observed between medial subchondral trabecular biomarkers and lateral tibial or femoral (medial or lateral) cartilage volume loss over the first and second follow-up years.CONCLUSIONS: Conventional MRI-derived subchondral trabecular biomarkers (higher medial cTbTh and cBV/TV) may be associated with increased medial tibial cartilage volume loss as early as 1 year.
U2 - 10.1007/s00256-022-04042-4
DO - 10.1007/s00256-022-04042-4
M3 - Journal article
C2 - 35366094
VL - 51
SP - 1959
EP - 1966
JO - Skeletal Radiology
JF - Skeletal Radiology
SN - 0364-2348
ER -
ID: 302809097