Transforming growth factor-β activation in cell-free extracellular matrix preparations: Commentary
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- 66341-195919-2-PB
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Transforming growth factor-β (TGF-β) is an important regulator of many cellular and immunological functions. It is often deposited in extracellular matrices in a latent form. This commentary is to draw attention to the likelihood that preparing cell-free matrices from tissue cultures by high pH buffers, such as ammonium hydroxide, can activate the TGF-β. Therefore, cells subsequently seeded onto such matrices may respond to the presence of active TGF-β in addition to interactions with macromolecular extracellular matrix components.
Original language | English |
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Journal | Folia Histochemica et Cytobiologica |
Volume | 57 |
Issue number | 4 |
Pages (from-to) | 157-158 |
ISSN | 0239-8508 |
DOIs | |
Publication status | Published - 2019 |
- Faculty of Health and Medical Sciences
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