Renal blood flow during exercise: understanding its measurement with Doppler ultrasound
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Renal blood flow during exercise: understanding its measurement with Doppler ultrasound. / Rocha, Marcos P; Mentetzides, Sandro H; Drew, Rachel C.
In: Journal of Applied Physiology, Vol. 134, No. 4, 2023, p. 1004-1010.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Renal blood flow during exercise: understanding its measurement with Doppler ultrasound
AU - Rocha, Marcos P
AU - Mentetzides, Sandro H
AU - Drew, Rachel C
N1 - CURIS 2023 NEXS 090
PY - 2023
Y1 - 2023
N2 - The sympathetic nervous system (SNS) has a critical role in continuously coordinating responses to stimuli internal and external to the human body by appropriately modulating the activity of the organs it innervates. The SNS is activated in response to various physiological stressors, including exercise, which can involve a significant increase in SNS activity. An increase in SNS activity directed towards the kidneys causes vasoconstriction of afferent arterioles within the kidneys. This sympathetically mediated renal vasoconstriction decreases renal blood flow (RBF), causing significant blood flow redistribution towards active skeletal muscles during exercise. In research studies, different modes, intensities, and durations of exercise have been used to investigate the sympathetically mediated RBF response to exercise, and several methodological approaches have been used to quantify RBF. Doppler ultrasound provides noninvasive, continuous, real-time measurements of RBF and has emerged as a valid and reliable technique to quantify RBF during exercise. This innovative methodology has been applied in studies in which the RBF response to exercise has been examined in healthy young and older adults and patient populations such as those with heart failure and peripheral arterial disease. This valuable tool has enabled researchers to produce clinically relevant findings that have furthered our understanding of the effect of SNS activation on RBF in populations of health and disease. Therefore, the focus of this narrative review is to highlight the use of Doppler ultrasound in research studies that has provided important findings furthering our knowledge of the impact of SNS activation on RBF regulation in humans.
AB - The sympathetic nervous system (SNS) has a critical role in continuously coordinating responses to stimuli internal and external to the human body by appropriately modulating the activity of the organs it innervates. The SNS is activated in response to various physiological stressors, including exercise, which can involve a significant increase in SNS activity. An increase in SNS activity directed towards the kidneys causes vasoconstriction of afferent arterioles within the kidneys. This sympathetically mediated renal vasoconstriction decreases renal blood flow (RBF), causing significant blood flow redistribution towards active skeletal muscles during exercise. In research studies, different modes, intensities, and durations of exercise have been used to investigate the sympathetically mediated RBF response to exercise, and several methodological approaches have been used to quantify RBF. Doppler ultrasound provides noninvasive, continuous, real-time measurements of RBF and has emerged as a valid and reliable technique to quantify RBF during exercise. This innovative methodology has been applied in studies in which the RBF response to exercise has been examined in healthy young and older adults and patient populations such as those with heart failure and peripheral arterial disease. This valuable tool has enabled researchers to produce clinically relevant findings that have furthered our understanding of the effect of SNS activation on RBF in populations of health and disease. Therefore, the focus of this narrative review is to highlight the use of Doppler ultrasound in research studies that has provided important findings furthering our knowledge of the impact of SNS activation on RBF regulation in humans.
KW - Faculty of Science
KW - Renal blood flow
KW - Renal vasoconstriction
KW - Sympathetic neural outflow to the kidneys
KW - Exercise
KW - Doppler ultrasound
U2 - 10.1152/japplphysiol.00392.2022
DO - 10.1152/japplphysiol.00392.2022
M3 - Review
C2 - 36892892
VL - 134
SP - 1004
EP - 1010
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 4
ER -
ID: 339953920