3D Ultrasound and MRI in Assessing Resection Margins during Tongue Cancer Surgery: A Research Protocol for a Clinical Diagnostic Accuracy Study
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3D Ultrasound and MRI in Assessing Resection Margins during Tongue Cancer Surgery : A Research Protocol for a Clinical Diagnostic Accuracy Study. / Makouei, Fatemeh; Agander, Tina Klitmøller; Ewertsen, Caroline; Svendsen, Morten Bo Søndergaard; Norling, Rikke; Kaltoft, Mikkel; Hansen, Adam Espe; Rasmussen, Jacob Høygaard; Wessel, Irene; Todsen, Tobias.
In: Journal of Imaging, Vol. 9, No. 9, 174, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - 3D Ultrasound and MRI in Assessing Resection Margins during Tongue Cancer Surgery
T2 - A Research Protocol for a Clinical Diagnostic Accuracy Study
AU - Makouei, Fatemeh
AU - Agander, Tina Klitmøller
AU - Ewertsen, Caroline
AU - Svendsen, Morten Bo Søndergaard
AU - Norling, Rikke
AU - Kaltoft, Mikkel
AU - Hansen, Adam Espe
AU - Rasmussen, Jacob Høygaard
AU - Wessel, Irene
AU - Todsen, Tobias
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023
Y1 - 2023
N2 - Surgery is the primary treatment for tongue cancer. The goal is a complete resection of the tumor with an adequate margin of healthy tissue around the tumor.Inadequate margins lead to a high risk of local cancer recurrence and the need for adjuvant therapies. Ex vivo imaging of the resected surgical specimen has been suggested for margin assessment and improved surgical results. Therefore, we have developed a novel three-dimensional (3D) ultrasound imaging technique to improve the assessment of resection margins during surgery. In this research protocol, we describe a study comparing the accuracy of 3D ultrasound, magnetic resonance imaging (MRI), and clinical examination of the surgical specimen to assess the resection margins during cancer surgery. Tumor segmentation and margin measurement will be performed using 3D ultrasound and MRI of the ex vivo specimen. We will determine the accuracy of each method by comparing the margin measurements and the proportion of correctly classified margins (positive, close, and free) obtained by each technique with respect to the gold standard histopathology.
AB - Surgery is the primary treatment for tongue cancer. The goal is a complete resection of the tumor with an adequate margin of healthy tissue around the tumor.Inadequate margins lead to a high risk of local cancer recurrence and the need for adjuvant therapies. Ex vivo imaging of the resected surgical specimen has been suggested for margin assessment and improved surgical results. Therefore, we have developed a novel three-dimensional (3D) ultrasound imaging technique to improve the assessment of resection margins during surgery. In this research protocol, we describe a study comparing the accuracy of 3D ultrasound, magnetic resonance imaging (MRI), and clinical examination of the surgical specimen to assess the resection margins during cancer surgery. Tumor segmentation and margin measurement will be performed using 3D ultrasound and MRI of the ex vivo specimen. We will determine the accuracy of each method by comparing the margin measurements and the proportion of correctly classified margins (positive, close, and free) obtained by each technique with respect to the gold standard histopathology.
KW - 3D ultrasound imaging
KW - ex vivo surgical specimen imaging
KW - magnetic resonance imaging
KW - oral cancer
KW - squamous cell carcinoma histopathology
KW - surgical margin assessment
KW - tongue squamous cell carcinoma
U2 - 10.3390/jimaging9090174
DO - 10.3390/jimaging9090174
M3 - Journal article
C2 - 37754938
AN - SCOPUS:85172176280
VL - 9
JO - Journal of Imaging
JF - Journal of Imaging
SN - 2313-433X
IS - 9
M1 - 174
ER -
ID: 369474163