Amiodarone protects diabetics and non-diabetics undergoing coronary artery bypass grafting equally
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: To evaluate amiodarone prophylaxis in diabetics and non-diabetics. Further to clarify whether the risk of developing atrial fibrillation is higher for diabetics than non-diabetic patients, and to evaluate whether the diabetic status has any influence on the length of in-hospital stay.
DESIGN: Subgroup analysis within a randomized, controlled, double-blinded trial.
RESULTS: At 30 days of follow-up atrial fibrillation was equally frequent among diabetics (22%) and non-diabetics (17%) (p =0.41). The length of in-hospital stay for diabetics was prolonged with 25% (9%; 45%). The prophylactic amiodarone was found equally efficient in diabetics and non-diabetics, as the relative risk ratios were 1.2 (0.4-5.4) and 2.0 (0.3-12.5), respectively.
CONCLUSIONS: Diabetics and non-diabetics had the same effect of the amiodarone prophylaxis regime. Atrial fibrillation developed equally among diabetics and non-diabetics, but the length of stay was prolonged for diabetics.
| Original language | English |
|---|---|
| Journal | Scandinavian Cardiovascular Journal |
| Volume | 42 |
| Issue number | 3 |
| Pages (from-to) | 173-7 |
| Number of pages | 5 |
| ISSN | 1401-7431 |
| DOIs | |
| Publication status | Published - Jun 2008 |
- Aged, Amiodarone/administration & dosage, Anti-Arrhythmia Agents/administration & dosage, Atrial Fibrillation/etiology, Coronary Artery Bypass/adverse effects, Coronary Artery Disease/drug therapy, Diabetes Mellitus/drug therapy, Double-Blind Method, Drug Administration Schedule, Female, Humans, Length of Stay, Male, Middle Aged, Risk Assessment, Time Factors, Treatment Outcome
Research areas
ID: 242714805