Diffusivity-limited q-space trajectory imaging
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Diffusivity-limited q-space trajectory imaging. / Boito, Deneb; Herberthson, Magnus; Dela Haije, Tom; Blystad, Ida; Özarslan, Evren.
In: Magnetic Resonance Letters, Vol. 3, No. 2, 2023, p. 187-196.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Diffusivity-limited q-space trajectory imaging
AU - Boito, Deneb
AU - Herberthson, Magnus
AU - Dela Haije, Tom
AU - Blystad, Ida
AU - Özarslan, Evren
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Q-space trajectory imaging (QTI) allows non-invasive estimation of microstructural features of heterogeneous porous media via diffusion magnetic resonance imaging performed with generalised gradient waveforms. A recently proposed constrained estimation framework, called QTI+, improved QTI's resilience to noise and data sparsity, thus increasing the reliability of the method by enforcing relevant positivity constraints. In this work we consider expanding the set of constraints to be applied during the fitting of the QTI model. We show that the additional conditions, which introduce an upper bound on the diffusivity values, further improve the retrieved parameters on a publicly available human brain dataset as well as on data acquired from healthy volunteers using a scanner-ready protocol.
AB - Q-space trajectory imaging (QTI) allows non-invasive estimation of microstructural features of heterogeneous porous media via diffusion magnetic resonance imaging performed with generalised gradient waveforms. A recently proposed constrained estimation framework, called QTI+, improved QTI's resilience to noise and data sparsity, thus increasing the reliability of the method by enforcing relevant positivity constraints. In this work we consider expanding the set of constraints to be applied during the fitting of the QTI model. We show that the additional conditions, which introduce an upper bound on the diffusivity values, further improve the retrieved parameters on a publicly available human brain dataset as well as on data acquired from healthy volunteers using a scanner-ready protocol.
KW - Constrained
KW - Diffusion
KW - Diffusion MRI
KW - Microscopic anisotropy
KW - Microstructure
KW - q-space trajectory imaging
KW - QTI
KW - QTI+
UR - http://www.scopus.com/inward/record.url?scp=85160379674&partnerID=8YFLogxK
U2 - 10.1016/j.mrl.2022.12.003
DO - 10.1016/j.mrl.2022.12.003
M3 - Journal article
AN - SCOPUS:85160379674
VL - 3
SP - 187
EP - 196
JO - Magnetic Resonance Letters
JF - Magnetic Resonance Letters
SN - 2772-5162
IS - 2
ER -
ID: 351237215