I am a professor in the Department of Computer Science and the head of the Center for Health Data Science (HeaDS) in the Faculty of Health and Medical Sciences. I have a Ph.D. in theoretical physics, but moved into machine learning and bioinformatics during my PhD. I have worked at UCSC, the Sanger Centre in Cambridge and at the Technical University of Denmark before joining the University of Copenhagen in 2002, where I was affiliated with the Department of Biology until 2020. I have worked in many areas of bioinformatics and machine learning, both with theory and applications. I am probably most well-known for my early work on hidden Markov models for biological sequences. In recent years I have focussed on deep generative models and applied them to gene expression data and other bio/medical data.