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Primary fields of research

My research is in medical image analysis with focus on imaging biomarkers, primarily of Alzheimer's disease (AD) and chronic obstructive pulmonary disease (COPD). This includes image processing and pattern recognition.

Selected publications (AD):

• Differential diagnosis of mild cognitive impairment and Alzheimer's disease using structural MRI cortical thickness, hippocampal shape, hippocampal texture, and volumetry / Sørensen, L., Igel, C., Pai, A., Balas, I., Anker, C., Lillholm, M., Nielsen, M. NeuroImage: Clinical 13: 470-482, 2017
• Early detection of Alzheimer’s disease using MRI hippocampal texture / Sørensen, L., Igel, C., Hansen, N.L., Osler, M., Lauritzen, M., Rostrup, E., Nielsen, M. Human Brain Mapping 37(3): 1148-1161, 2016
• Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: the CADDementia challenge / Bron, E.E., ..., Sørensen, L., et al. NeuroImage 111: 562-579, 2015

Selected publications (COPD):

• Transfer Learning for Multi-Center Classification of Chronic Obstructive Pulmonary Disease / Cheplygina, V., Peña, I.P., Pedersen, J.J.H, Lynch, D.A., Sørensen, L., de Bruijne, M. IEEE Journal of Biomedical and Health Informatics, 2018
• Texture-Based Analysis of COPD: a Data-Driven Approach / Sørensen, L., Nielsen, M., Lo, P., Ashraf, H., Pedersen, J.J.H., de Bruijne, M. L. Sørensen, M. Nielsen, P. Lo, H. Ashraf, J.J.H. Pedersen, and M. de Bruijne. IEEE Transactions on Medical Imaging 31(1): 70-78, 2012
• Quantitative analysis of pulmonary emphysema using local binary patterns / Sørensen, L., Shaker S.B., de Bruijne, M. IEEE Transactions on Medical Imaging 29(2): 559-569, 2010

Selected publications (dissimilarity-based multiple instance learning):

• Dissimilarity-Based Classification of Anatomical Tree Structures / Sørensen, L., Lo, P., Dirksen, A., Petersen, J., de Bruijne, M. In: Information Processing in Medical Imaging (IPMI), 2011
• Image dissimilarity-based quantification of lung disease from CT / Sørensen, L., Loog, M., Lo, P., Ashraf, H., Dirksen, A., Duin, R.P.W., de Bruijne, M. In: Medical Image Computing and Computer Assisted Intervention (MICCAI), 2010
• Dissimilarity-based multiple instance learning / Sørensen, L., Loog, M., Tax, D.M.J., Lee, W.-J., de Bruijne, M., Duin, R.P.W. In: Statistical, Structural and Syntactic Pattern Recognition (S+SSPR), 2010

Selected publications (other)

• Training recurrent neural networks robust to incomplete data: application to Alzheimer's disease progression modeling / Ghazi, M.M., Nielsen, M., Pai, A., Cardoso, M.J., Modat, M., Ourselin, S., and Sørensen, L. Medical Image Analysis, accepted
• Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953 / Osler, M., Sørensen, L., Rozing, M., Calvo, O., Nielsen, M., Rostrup, E. Human Brain Mapping 39(4): 1789-1795, 2018

Resources:

• Computed Tomography Emphysema Database
• COPD Machine Learning Datasets

Current research

• Hippocampal texture as an early T1-weighted structural MRI biomarker of Alzheimer's disease
• Combination of MRI biomarkers for imporved Alzheimer's disease diagnosis
• Alzheimer's disease progression modelling using multiple biomarkers