I am professor of Bioinformatics and the head of the Section for Computational and RNA Biology in the Department of Biology. I have a Ph.D. in theoretical physics, but moved into bioinformatics in 1991 as a postdoc at UCSC. Since then I have worked at the Sanger Centre in Cambridge and at the Technical University of Denmark before joining the University of Copenhagen in 2002. I have worked in many areas of bioinformatics, both with theory and applications. I am probably most well known for early work on hidden Markov models for biological sequences. In recent years I have focussed on analysis of data from high-throughput DNA sequencing with applications in post-transcriptional regulation, ancient genomics, metagenomics, and transcriptome analysis.