miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
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miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. / Bou Kheir, Tony; Futoma-Kazmierczak, Ewa; Jacobsen, Anders; Krogh, Anders; Bardram, Linda; Hother, Christoffer; Grønbæk, Kirsten; Federspiel, Birgitte; Lund, Anders H; Friis-Hansen, Lennart Jan.
In: Molecular Cancer, Vol. 10, 2011, p. 1-12.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - miR-449 inhibits cell proliferation and is down-regulated in gastric cancer
AU - Bou Kheir, Tony
AU - Futoma-Kazmierczak, Ewa
AU - Jacobsen, Anders
AU - Krogh, Anders
AU - Bardram, Linda
AU - Hother, Christoffer
AU - Grønbæk, Kirsten
AU - Federspiel, Birgitte
AU - Lund, Anders H
AU - Friis-Hansen, Lennart Jan
PY - 2011
Y1 - 2011
N2 - Gastric cancer is the fourth most common cancer in the world and the second most prevalent cause of cancer related death. The development of gastric cancer is mainly associated with H. Pylori infection leading to a focus in pathology studies on bacterial and environmental factors, and to a lesser extent on the mechanistic development of the tumour. MicroRNAs are small non-coding RNA molecules involved in post-transcriptional gene regulation. They are found to regulate genes involved in diverse biological functions and alterations in microRNA expression have been linked to the pathogenesis of many malignancies. The current study is focused on identifying microRNAs involved in gastric carcinogenesis and to explore their mechanistic relevance by characterizing their targets.
AB - Gastric cancer is the fourth most common cancer in the world and the second most prevalent cause of cancer related death. The development of gastric cancer is mainly associated with H. Pylori infection leading to a focus in pathology studies on bacterial and environmental factors, and to a lesser extent on the mechanistic development of the tumour. MicroRNAs are small non-coding RNA molecules involved in post-transcriptional gene regulation. They are found to regulate genes involved in diverse biological functions and alterations in microRNA expression have been linked to the pathogenesis of many malignancies. The current study is focused on identifying microRNAs involved in gastric carcinogenesis and to explore their mechanistic relevance by characterizing their targets.
U2 - 10.1186/1476-4598-10-29
DO - 10.1186/1476-4598-10-29
M3 - Journal article
C2 - 21418558
VL - 10
SP - 1
EP - 12
JO - Molecular Cancer
JF - Molecular Cancer
SN - 1476-4598
ER -
ID: 33255927