Supervised hub-detection for brain connectivity

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

A structural brain network consists of physical connections between brain regions. Brain network analysis aims to find features associated with a parameter of interest through supervised prediction models such as regression. Unsupervised preprocessing steps like clustering are often applied, but can smooth discriminative signals in the population, degrading predictive performance. We present a novel hub-detection optimized for supervised learning that both clusters network nodes based on population level variation in connectivity and also takes the learning problem into account. The found hubs are a low-dimensional representation of the network and are chosen based on predictive performance as features for a linear regression. We apply our method to the problem of finding age-related changes in structural connectivity. We compare our supervised hub-detection (SHD) to an unsupervised hub-detection and a linear regression using the original network connections as features. The results show that the SHD is able to retain regression performance, while still finding hubs that represent the underlying variation in the population. Although here we applied the SHD to brain networks, it can be applied to any network regression problem. Further development of the presented algorithm will be the extension to other predictive models such as classification or non-linear regression. textcopyright (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Original languageEnglish
Title of host publicationMedical Imaging 2016 : Image Processing
EditorsMartin A. Styner, Elsa D. Angelini
Number of pages9
PublisherSPIE - International Society for Optical Engineering
Publication date2016
Article number978409
ISBN (Print)978-1-51060-019-5
Publication statusPublished - 2016
EventSPIE Medical Imaging 2016 - San Diego, Cal., United States
Duration: 27 Feb 20163 Mar 2016


ConferenceSPIE Medical Imaging 2016
LandUnited States
BySan Diego, Cal.
SeriesProgress in Biomedical Optics and Imaging

ID: 160636311