Identifying recurrent breast cancer patients in national health registries using machine learning
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Identifying recurrent breast cancer patients in national health registries using machine learning. / Lauritzen, Andreas David; Berg, Tobias; Jensen, Maj-Britt; Lillholm, Martin; Knoop, Ann.
In: Acta Oncologica, Vol. 62, No. 4, 2023, p. 350–357.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Identifying recurrent breast cancer patients in national health registries using machine learning
AU - Lauritzen, Andreas David
AU - Berg, Tobias
AU - Jensen, Maj-Britt
AU - Lillholm, Martin
AU - Knoop, Ann
PY - 2023
Y1 - 2023
N2 - BackgroundMore than 4500 women are diagnosed with breast cancer each year in Denmark, however, despite adequate treatment 10-30% of patients will experience a recurrence. The Danish Breast Cancer Group (DBCG) stores information on breast cancer recurrence but to improve data completeness automated identification of patients with recurrence is needed.MethodsWe included patient data from the DBCG, the National Pathology Database, and the National Patient Registry for patients with an invasive breast cancer diagnosis after 1999. In total, relevant features of 79,483 patients with a definitive surgery were extracted. A machine learning (ML) model was trained, using a simplistic encoding scheme of features, on a development sample covering 5333 patients with known recurrence and three times as many non-recurrent women. The model was validated in a validation sample consisting of 1006 patients with unknown recurrence status.ResultsThe ML model identified patients with recurrence with AUC-ROC of 0.93 (95% CI: 0.93-0.94) in the development, and an AUC-ROC of 0.86 (95% CI: 0.83-0.88) in the validation sample.ConclusionAn off-the-shelf ML model, trained using the simplistic encoding scheme, could identify recurrence patients across multiple national registries. This approach might potentially enable researchers and clinicians to better and faster identify patients with recurrence and reduce manual patient data interpretation.
AB - BackgroundMore than 4500 women are diagnosed with breast cancer each year in Denmark, however, despite adequate treatment 10-30% of patients will experience a recurrence. The Danish Breast Cancer Group (DBCG) stores information on breast cancer recurrence but to improve data completeness automated identification of patients with recurrence is needed.MethodsWe included patient data from the DBCG, the National Pathology Database, and the National Patient Registry for patients with an invasive breast cancer diagnosis after 1999. In total, relevant features of 79,483 patients with a definitive surgery were extracted. A machine learning (ML) model was trained, using a simplistic encoding scheme of features, on a development sample covering 5333 patients with known recurrence and three times as many non-recurrent women. The model was validated in a validation sample consisting of 1006 patients with unknown recurrence status.ResultsThe ML model identified patients with recurrence with AUC-ROC of 0.93 (95% CI: 0.93-0.94) in the development, and an AUC-ROC of 0.86 (95% CI: 0.83-0.88) in the validation sample.ConclusionAn off-the-shelf ML model, trained using the simplistic encoding scheme, could identify recurrence patients across multiple national registries. This approach might potentially enable researchers and clinicians to better and faster identify patients with recurrence and reduce manual patient data interpretation.
KW - Breast cancer
KW - machine learning
KW - recurrence
KW - DBCG
U2 - 10.1080/0284186X.2023.2201687
DO - 10.1080/0284186X.2023.2201687
M3 - Journal article
C2 - 37074036
VL - 62
SP - 350
EP - 357
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 4
ER -
ID: 347313666